157472-96-3

Basic information

• Product Name: 1,1,2,2 - tetraMethyl - 1,2 - ethanediaMino - N,N' - bis(3,5 - di - tert - butylsalicylidene) - cobalt(II)
• Synonyms: 1,1,2,2 - tetraMethyl - 1,2 - ethanediaMino - N,N' - bis(3,5 - di - tert - butylsalicylidene) - cobalt(II)
• CAS NO: 157472-96-3
• Molecular Formula: C36H54CoN2O2
• Molecular Weight: 605.77
• Mol File: 157472-96-3.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,1,2,2 - tetraMethyl - 1,2 - ethanediaMino - N,N' - bis(3,5 - di - tert - butylsalicylidene) - cobalt(II)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1,2,2 - tetraMethyl - 1,2 - ethanediaMino - N,N' - bis(3,5 - di - tert - butylsalicylidene) - cobalt(II)(157472-96-3)
• EPA Substance Registry System: 1,1,2,2 - tetraMethyl - 1,2 - ethanediaMino - N,N' - bis(3,5 - di - tert - butylsalicylidene) - cobalt(II)(157472-96-3)

Safety Data

• Hazardous Substances Data: 157472-96-3(Hazardous Substances Data)

Upstream product

• 351498-10-7 N,N’-bis(3,5-di-tert-butylsalicylidene)-1,1,2,2-tetramethylethenediamine 
• 71-48-7 cobalt(II) acetate 
• 1448441-99-3 2,4-di-tert-butyl- 6-[(E)-{2-[(E)-(3,5-di-tert-butyl-2-hydroxyphenyl)-methyleneamino]-1,1,2-trimethylpropyl}iminomethyl]phenol 
• 20485-44-3 2,3-dimethyl-2,3-diaminobutane 
• 37942-07-7 3,5-di-tert-butyl-2-hydroxybenzaldehyde 
• 6147-53-1 cobalt(II) diacetate tetrahydrate 

Relevant articles and documents

[N,N′-(1,1,2,2-tetramethylethylene)bis(3,5-di-tert- butylsalicylideneiminato)] cobalt(II) 1

Dimerization of the molecule of the title compound, [Co(C36H54N2O2)], an efficient dioxygen carrier, is prevented by the methyl and tert-butyl substituents. The square-planar complex is bisected by a crystallographic mirror plane, with disorder of the -CMe2 - CMe2-region. Molecular dimensions [Co - O 1.846(2) and Co - N 1.850 (2) A] are very similar to those of the related 3-tert-butylsalicylidenato complex.

2′-Modified Guanosine Analogs for the Treatment of HCV

Novel 2′-modified guanosine nucleosides were synthesized from inexpensive starting materials in 7–10 steps via hydroazidation or hydrocyanation reactions of the corresponding 2′-olefin. The antiviral effectiveness of the guanosine nucleosides was evaluated by converting them to the corresponding 5′-O-triphosphates (compounds 38–44) and testing their biochemical inhibitory activity against the wild-type NS5B polymerase.

2'-CYANO SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF USEFUL FOR THE TREATMENT OF VIRAL DISEASES

The present invention relates to 2′-Cyano Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2 and R3 are as defined herein. The present invention also relates to compositions comprising at least one 2′-Cyano Substituted Nucleoside Derivative, and methods of using the 2′-Cyano Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.