157491-63-9Relevant academic research and scientific papers
Rational hopping of a peptidic scaffold into non-peptidic scaffolds: Structurally novel potent proteasome inhibitors derived from a natural product, belactosin A
Kawamura, Shuhei,Unno, Yuka,Hirokawa, Takatsugu,Asai, Akira,Arisawa, Mitsuhiro,Shuto, Satoshi
supporting information, p. 2445 - 2447 (2014/03/21)
Rational scaffold hopping of a natural product belactosin A derivative was successfully achieved based on the pharmacophore model constructed. The peptidic scaffold was replaced by significantly simplified non-peptidic scaffolds, by which weak belactosin A (IC50 = 1440 nM) was converted into highly potent non-peptidic inhibitors (IC50 = 26-393 nM).
COMPLEXES OF 4-HYDROPEROXY IFOSFAMIDE AS ANTI-TUMOR AGENTS
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Page/Page column 22-23, (2010/09/17)
The present disclosure concerns complexes of 4-hydroperoxy ifosfamide. In one embodiment the complexes can be represented by the formula (A); wherein A represents an ammonium species selected from the conjugate acid of a basic amino acid, quaternary ammonium, aliphatic ammonium, heterocyclic ammonium, aromatic ammonium, substituted and unsubstituted pyridinium, guanidinium, and amidinium, and wherein X and Y independently represent leaving groups. Also disclosed herein are methods for making such compounds and formulating pharmaceutical compositions thereof. Methods for administering the disclosed compounds to subjects, particularly to treat hyperproliferative disorders, also are disclosed.
Synthesis of β-lactones by the photochemical reactions of chromium alkoxycarbene complexes with aldehydes
Colson,Hegedus
, p. 4972 - 4976 (2007/10/02)
Photolysis of chromium alkoxycarbene complexes with aldehydes in the presence of Lewis acids produced β-lactones in low yield. Incorporation of the aldehyde into either side chain of the carbene complex resulted in intramolecular processes which were considerably more efficient.
