157503-18-9

Basic information

• Product Name: 6-Maleimido-1-hexanol
• Synonyms: 6-Maleimido-1-hexanol;1-(6-Hydroxyhexyl)-;1H-Pyrrole-2,5-dione, 1-(6-hydroxyhexyl)-;N-(6-Hydroxyhexyl)maleimide
• CAS NO: 157503-18-9
• Molecular Formula: C₁₀H₁₅NO₃
• Molecular Weight: 197.231
• EINECS: -0
• Product Categories: Amines;Heterocycles;Amines, Heterocycles, MTS & Sulfhydryl Active Reagents
• Mol File: 157503-18-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 348.0±25.0 °C(Predicted)
• Appearance: /
• Density: 1.179±0.06 g/cm3(Predicted)
• Storage Temp.: Room Temperature, Under Inert Atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 15.17±0.10(Predicted)
• CAS DataBase Reference: 6-Maleimido-1-hexanol(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Maleimido-1-hexanol(157503-18-9)
• EPA Substance Registry System: 6-Maleimido-1-hexanol(157503-18-9)

Safety Data

• Hazardous Substances Data: 157503-18-9(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

6-Maleimido-1-hexanol is used in the preparation of water-soluble saccharide conjugates and saccharide mimetics by Diels-Alder reaction.

Upstream product

• 55750-48-6 N-methoxycarbonylmaleimide 
• 4048-33-3 6-amino-1-hexanol 
• 541-59-3 maleiimide 
• 108-31-6 maleic anhydride 
• 55750-53-3 2,5-Dihydro-2,5-dioxo-1H-pyrrole-1-hexanoic acid 

Downstream Products

• 97725-90-1 4-<2-Diaethylphosphono-vinyl>-cyclohexen-1-phosphonsaeure-(3)-diaethylester 
• 1076198-37-2 6-(2,5-dioxo-2,5-dihydro-1 H-pyrrol-1-yl)hexanal 
• 847757-11-3 Toluene-4-sulfonic acid (S)-3-[6-((1R,2S,6R,7S)-3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl)-hexyloxy]-2-hydroxy-propyl ester 

Relevant articles and documents

Orthogonal functionalization of a fullerene building block through copper-catalyzed alkyne-azide and thiol-maleimide click reactions

In this study, the synthesis of an orthogonally clickable fullerene building block mono-adduct bearing on one side an alkyne unit and a maleimide moiety on the other side is presented. This derivative has been involved in CuAAC and thiol-maleimide click reactions using stepwise or one-pot processes with benzyl azide and 1-octanethiol. The one-pot process involving the CuAAC reaction followed by the thiol-maleimide conjugation gives the highest yield. This new platform could pave the way for the synthesis of a wide range of fullerene derivatives exploiting this set of orthogonal reactions.

ANTIBODY DRUG CONJUGATES

This application discloses anti-P-cadherin antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments, particularly antibody drug conjugates comprising anti-P-cadherin antibodies conjugated to auristatin analogs. The invention also relates to methods of treating cancer using the antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.

Antibody-Drug Conjugates, Compositions and Methods of Use

Antibody-cytotoxin antibody-drug conjugates and related compounds, such as linker-cytotoxin conjugates and the linkers used to make them, tubulysin analogs, and intermediates in their synthesis; compositions; and methods, including methods of treating can