157523-39-2Relevant academic research and scientific papers
Regiodivergent synthesis of trisubstituted furans through Tf 2O-catalyzed Friedel-Crafts acylation: A tool for access to tetrahydrofuran lignan analogues
Comegna, Daniela,Dellagreca, Marina,Rosaria Iesce,Previtera, Lucio,Zarrelli, Armando,Zuppolini, Simona
experimental part, p. 1219 - 1224 (2012/03/07)
3-or 4-Aroylfurans have been prepared selectively and in high yields from a common precursor by simple tuning of reaction conditions in Friedel-Crafts acylation promoted by triflic anhydride. The formation of products can be explained on the basis of the ring-chain tautomerism occurring in compounds equipped with two neighbouring carboxylic functions. Since 4-aroylfuran derivatives show a typical lignan backbone, suitable hydrogenation conditions were found out to gain tetrahydrofuran lignans. The Royal Society of Chemistry 2012.
