157559-76-7Relevant academic research and scientific papers
Synthesis and HPLC-separation of chiral 1,3,4-thiadiazines and 1,3,4-selenadiazines
Jira, Thomas,Stelzer,Pfeiffer,Schopplich,Siegert,Kindermann
, p. 831 - 835 (2007/10/03)
The reaction of 4-isopropylthiosemicarbazide and 4-alkyl(aryl)-2-methylthiosemicarbazides and -selenosemicarbazides, respectively, with α-halogenketones yields 1,3,4-thiadiazines and 1,3,4-selenadiazines. In the presence of acids or bases the title compou
Syntheses and HPLC separation of chiral 1,3,4-thiadiazines and 1,3,4-selenadiazines
Jira,Pfeiffer,Lachmann,Epperlein
, p. 401 - 406 (2007/10/02)
The reaction of 4-isopropylthiosemicarbazide and 4-alkyl(aryl)-2-methyl-thiosemicarbazides and -selenosemicarbazides, respectively, with α-halogenketones gives 1,3,4-thiadiazines and 1,3,4-selenadiazines. The titel compounds undergo, in the presence of acids or bases, ring contraction with extrusion of sulphur and selenium, respectively, and formation of pyrazoles. Studies in this work are reported analytical HPLC separations of chiral 1,3,4-thiadiazines and 1,3,4-selenadiazines, respectively, on different chiral stationary phases (CSP). The influence of various charged and uncharged modifiers in the mobile phase on the chromatographic resolution is discussed.
