157561-90-5 Usage
General Description
2-Propenamide, 2-cyano-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)- is a chemical compound with the molecular formula C13H8N4O. It is a derivative of 2-propenamide and contains a cyano group and a pyrrolopyridine ring. 2-Propenamide, 2-cyano-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)- has potential applications in pharmaceutical research and drug development due to its structural features and potential biological activities. It may also be used as a building block in organic synthesis for the production of various complex molecules. Further research is needed to fully understand the properties and potential uses of this chemical.
Check Digit Verification of cas no
The CAS Registry Mumber 157561-90-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,7,5,6 and 1 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 157561-90:
(8*1)+(7*5)+(6*7)+(5*5)+(4*6)+(3*1)+(2*9)+(1*0)=155
155 % 10 = 5
So 157561-90-5 is a valid CAS Registry Number.
InChI:InChI=1/C11H8N4O/c12-5-7(10(13)16)4-8-6-15-11-9(8)2-1-3-14-11/h1-4,6H,(H2,13,16)(H,14,15)
157561-90-5Relevant articles and documents
Electrophilic fragment-based design of reversible covalent kinase inhibitors
Miller, Rand M.,Paavilainen, Ville O.,Krishnan, Shyam,Serafimova, Iana M.,Taunton, Jack
supporting information, p. 5298 - 5301 (2013/06/05)
Fragment-based ligand design and covalent targeting of noncatalytic cysteines have been employed to develop potent and selective kinase inhibitors. Here, we combine these approaches, starting with a panel of low-molecular- weight, heteroaryl-susbstituted cyanoacrylamides, which we have previously shown to form reversible covalent bonds with cysteine thiols. Using this strategy, we identify electrophilic fragments with sufficient ligand efficiency and selectivity to serve as starting points for the first reported inhibitors of the MSK1 C-terminal kinase domain. Guided by X-ray co-crystal structures, indazole fragment 1 was elaborated to afford 12 (RMM-46), a reversible covalent inhibitor that exhibits high ligand efficiency and selectivity for MSK/RSK-family kinases. At nanomolar concentrations, 12 blocked activation of cellular MSK and RSK, as well as downstream phosphorylation of the critical transcription factor, CREB.
