1575656-56-2Relevant articles and documents
One-Pot Directing Group Formation/C?H Bond Functionalization via Copper(I) and Ruthenium(II) Catalysis
Bruneau, Christian,Gramage-Doria, Rafael
supporting information, p. 3847 - 3856 (2016/12/16)
A copper(I)-catalyzed oxidation leading to the formation of 2-pyridyl ketone directing groups has been efficiently coupled with a ruthenium(II)-catalyzed C(sp2)?H bond arylation transformation without performing any intermediate work-up. This sustainable approach was further extended to sequential three-step transition metal-catalyzed transformations in which up to four new bonds (C–O, C–C, C–H and O–H) are formed in a one-pot fashion. This is the first example in which two different transition metal catalysts are sequentially employed for the directing group formation and the C?H bond functionalization, respectively. (Figure presented.).