1575819-54-3

Basic information

• Product Name: benzyl N-[[1-[1-[4-(tert-butoxycarbonylamino)-2-cyano-4-methyl-pent-2-enoyl]-3-piperidyl]-2-[(4-chlorobenzoyl)amino]benzimidazol-5-yl]methyl]-N-[(1S)-1,2,2-trimethylpropyl]carbamate
• Synonyms: benzyl N-[[1-[1-[4-(tert-butoxycarbonylamino)-2-cyano-4-methyl-pent-2-enoyl]-3-piperidyl]-2-[(4-chlorobenzoyl)amino]benzimidazol-5-yl]methyl]-N-[(1S)-1,2,2-trimethylpropyl]carbamate
• CAS NO: 1575819-54-3
• Molecular Weight: 838.447
• Mol File: 1575819-54-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: benzyl N-[[1-[1-[4-(tert-butoxycarbonylamino)-2-cyano-4-methyl-pent-2-enoyl]-3-piperidyl]-2-[(4-chlorobenzoyl)amino]benzimidazol-5-yl]methyl]-N-[(1S)-1,2,2-trimethylpropyl]carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl N-[[1-[1-[4-(tert-butoxycarbonylamino)-2-cyano-4-methyl-pent-2-enoyl]-3-piperidyl]-2-[(4-chlorobenzoyl)amino]benzimidazol-5-yl]methyl]-N-[(1S)-1,2,2-trimethylpropyl]carbamate(1575819-54-3)
• EPA Substance Registry System: benzyl N-[[1-[1-[4-(tert-butoxycarbonylamino)-2-cyano-4-methyl-pent-2-enoyl]-3-piperidyl]-2-[(4-chlorobenzoyl)amino]benzimidazol-5-yl]methyl]-N-[(1S)-1,2,2-trimethylpropyl]carbamate(1575819-54-3)

Safety Data

• Hazardous Substances Data: 1575819-54-3(Hazardous Substances Data)

Upstream product

• 1575819-51-0 benzyl (1-(1-acryloylpiperidin-3-yl)-2-(4-chlorobenzamido)-1H-benzo[d]imidazol-5-yl)methyl((S)-3,3-dimethylbutan-2-yl)carbamate 
• 1575819-49-6 tert-butyl 3-(5-(((benzyloxycarbonyl)-((S)-3,3-dimethylbutan-2-yl)amino)methyl)-2-(4-chlorobenzamido)-1H-benzo[d]imidazol-1-yl)piperidine-1-carboxylate 
• 1575819-48-5 tert-butyl 3-(5-(((benzyloxycarbonyl)((S)-3,3-dimethylbutan-2-yl)amino)methyl)-2-imino-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-1-carboxylate 
• 1575819-47-4 tert-butyl 3-(2-amino-4-(((benzyloxycarbonyl)((S)-3,3-dimethylbutan-2-yl)amino)methyl)-phenylamino)-piperidine-1-carboxylate 
• 1575819-46-3 tert-butyl 3-(4-(((benzyloxycarbonyl)((S)-3,3-dimethylbutan-2-yl)amino)methyl)-2-nitrophenylamino)-piperidine-1-carboxylate 
• 1575819-45-2 tert-butyl 3-(4-(((S)-3,3-dimethylbutan-2-ylamino)methyl)-2-nitrophenyl-amino)piperidine-1-carboxylate 
• 1575819-44-1 tert-butyl 3-(4-formyl-2-nitrophenylamino)piperidine-1-carboxylate 
• 42564-51-2 4-fluoro-3-nitrobenzaldehyde 
• 144243-24-3 tert‐butyl 3‐aminopiperidine‐1‐carboxylate 
• 1575819-53-2 benzyl (2-(4-chlorobenzamido)-1-(1-(2-cyanoacetyl)piperidine-3-yl)-1H-benzo[d]imidazol-5-yl)methyl((S)-3,3-dimethylbutan-2-yl)carbamate 
• 109608-77-7 2-tert-butoxycarbonylamino-2-methylpropanal 

Relevant articles and documents

BENZIMIDAZOLE DERIVATIVES AS ITK INHIBITORS

The present disclosure is directed to certain inhibitors of kinases such as ITK, BLK, BMX, BTK, JAK3, TEC, TXK, HER2 (ERBB2), or HER4 (ERBB4), in particular ITK, pharmaceutical compositions comprising such compounds, and method of treating diseases mediated by such kinases.