157604-46-1

Basic information

• Product Name: 3-(1,1-DIMETHYLETHYL)-4-METHYL-(R,S)-2,2-DIMETHYL-3,4-OXAZOLIDINEDICARBOXYLATE
• Synonyms: 3-(1,1-DIMETHYLETHYL)-4-METHYL-(R,S)-2,2-DIMETHYL-3,4-OXAZOLIDINEDICARBOXYLATE;METHYL 3-(TERT-BUTOXYCARBONYL)-2, 2-DIMETHYL-4-OXAZOLIDINECARBOXYLATE;(S)-N-BOC-2,2-DIMETHYLOXAZOLINDINE-4-CARBOX YLIC ACID METHL ESTER;3-(1,1-dimethylethyl)-4-methyl-(R,S)-2,2-dimethyl-3,4-oxazolidinedicarboxylate, 95 %;3-tert-butyl 4-Methyl 2,2-diMethyloxazolidine-3,4-dicarboxylate
• CAS NO: 157604-46-1
• Molecular Formula: C₁₂H₂₁NO₅
• Molecular Weight: 259.3
• Product Categories: chiral
• Mol File: 157604-46-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Refractive Index: 1.474
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(1,1-DIMETHYLETHYL)-4-METHYL-(R,S)-2,2-DIMETHYL-3,4-OXAZOLIDINEDICARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1,1-DIMETHYLETHYL)-4-METHYL-(R,S)-2,2-DIMETHYL-3,4-OXAZOLIDINEDICARBOXYLATE(157604-46-1)
• EPA Substance Registry System: 3-(1,1-DIMETHYLETHYL)-4-METHYL-(R,S)-2,2-DIMETHYL-3,4-OXAZOLIDINEDICARBOXYLATE(157604-46-1)

Safety Data

• Hazardous Substances Data: 157604-46-1(Hazardous Substances Data)

Usage

General Description

The chemical 3-(1,1-dimethylethyl)-4-methyl-(R,S)-2,2-dimethyl-3,4-oxazolidinedicarboxylate, also known as L-carnitine or levocarnitine, is a naturally occurring compound that plays a crucial role in the transportation of fatty acids into the mitochondria, where they can be converted into energy. It is commonly used as a dietary supplement to support energy production and muscle function, as well as to improve endurance and athletic performance. Additionally, L-carnitine has been studied for its potential benefits in managing conditions such as heart disease, diabetes, and certain neurological disorders. The compound is considered safe when used as directed, but excessive intake can lead to side effects such as nausea, vomiting, and diarrhea.

InChI:InChI=1/C12H21NO5/c1-10(2,3)18-9(16)13-11(4,5)17-7-12(13,6)8(14)15/h7H2,1-6H3,(H,14,15)/t12-/m1/s1

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 69942-12-7 N-tert-butoxycarbonylserine methyl ester 
• 77-76-9 2,2-dimethoxy-propane 

Downstream Products

• 95715-86-9 (S)-2,2-dimethyl-oxazolidine-3,4-dicarboxylic acid 3-tert-butyl ester 4-methyl ester 
• 108149-60-6 methyl [(4R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]carboxylate 
• 95715-87-0 tert-butyl 4-formyl-2,2-dimethyloxazolidine-3-carboxylate 
• 108149-63-9 4-hydroxymethyl-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester 
• 108149-63-9 tert-butyl (4S)-4-(hydroxymethyl)-2,2-dimethyl-1,3-oxazolidine-3-carboxylate 

Relevant articles and documents

BIARYL KINASE INHIBITORS

The present disclosure is directed to biaryl compounds of formula (I) which can inhibit AAKl (adaptor associated kinase 1), compositions comprising such compounds and their use for treating e.g. pain, Alzheimer's disease, Parkinson's disease and schizophrenia.

A solid-phase approach to DDB derivatives

Since the discovery of 2,2′-dimethoxycarbonyl-4,4-dimethoxy-5,6, 5′,6′-biomethylenedioxy-biphenyl (DDB) as a potent anti-HBV agent, we have studied the structure-activity relationships of 4,4′-dimethoxy-5, 6,5′,6′-dimethenedioxy-2-alkyloxycarbonyl-2′-(4-substituted benzyl piperazin-1-yl)carbonyl-biphenyl as anti-HBV agents. Therefore, it is rational to extend this study to the 3,3′-disustituted-4,4′- dimethoxy-5,6,5′,6′-dimethenedioxy-2-alkyloxycarbonyl-2′- Serine derivatives. Thus, in an attempt to develop an efficient method for the preparation of a large number of DDB derivatives, the reaction between a DDB acid chloride and serine derivatives on solid support was studied. The structure of resulted compounds was confirmed by LC-MS and 1H NMR analysis. Compounds 2a, 2d, 2f, 2j showed in vitro anti-HBV activity without significant toxicity up to 100 μM.