157604-58-5

Upstream product

• 110115-17-8 methyl (1R,2S)-2-(hydroxymethyl)cyclopropane-1-carboxylate 
• 157523-15-4 2-tosyloxymethyl-7-oxa-2,3-diazabicyclo<3.3.0>oct-2-en-8-one 
• 159950-58-0 (1R,4S,5S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-3-oxa-bicyclo[3.1.0]hexan-2-one 
• 159950-60-4 (1R,4S,5S)-4-Iodomethyl-3-oxa-bicyclo[3.1.0]hexan-2-one 
• 159950-59-1 (1R,4S,5S)-4-hydroxymethyl-3-oxabicyclo[3.1.0]hexan-2-one 
• 160022-44-6 (1R,2R)-2-Vinyl-cyclopropanecarboxylic acid 
• 157523-16-5 Toluene-4-sulfonic acid (1S,2S,5R)-4-oxo-3-oxa-bicyclo[3.1.0]hex-2-ylmethyl ester 
• 106820-48-8 (3aS,4S,6aR)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-3,3a,4,6a-tetrahydro-furo[3,4-c]pyrazol-6-one 
• 160022-45-7 cis-2-Vinyl-cyclopropancarbonsaeuremethylester 
• 157523-17-6 methyl (1R,2S,2'S)-2-(oxiran-2'-yl)cyclopropanecarboxylate 

Relevant academic research and scientific papers

Synthesis of Methyl (1R,2S)-2-cyclopropanecarboxylate: a Potential Inhibitor of the Enzyme 5-Lipoxygenase

We describe the synthesis of a novel cyclopropyl analogue of arachidonic acid via a convergent synthesis that employed methyl (1R,2S)-2-formylcyclopropanecarboxylate in conjunction with the ylide from (3Z,6Z)-pentadeca-3,6-dienyl(triphenyl)phosphonium iod

MACROCYCLIC INHIBITORS OF PEPTIDYLARGININE DEIMINASES

The present disclosure relates to novel compounds for use in therapeutic treatement of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.

Controlling π-Facial Diastereoselectivity in the 1,3-Dipolar Cycloadditions of Diazomethane to Chiral Pentenoates and Furanones: Enantioselective Stereodivergent Syntheses of Cyclopropane Hydroxy Acids and Didehydro Amino Acids

The title compounds have been synthesized in both enantiomeric forms and in good overall yields by using D-glyceraldehyde as the single chiral precursor. The efficiency and usefulness of the synthetic routes have been secured by performing controlled manipulations of the functional groups and by highly stereoselective transformations, namely Wittig-Horner condensations and cyclopropanations. Cyclopropane derivatives have been synthesized through 1,3-dipolar cycloaddition of diazomethane to chiral pentenoates or furanones obtained, in turn, from D-glyceraldehyde. Syn/ anti stereochemistry of the cycloadducts has been unequivocally assigned and rationalized. Since π-facial diastereoselectivity involved in these cycloadditions is the opposite for cyclic and open- chain structures, enantiomeric series of products can be derived.

Stereoselective synthesis of enantiopure cyclopropane didehydroamino acid derivatives: (-)-(Z)-2-benzyloxycarbonylamino-4,5-cyclopropane-2-hexenodioic acid dimethyl ester

The title amino acid derivative has been synthesized stereoselectively in 40% overall yield from 5-tert-butyldiphenylsilyloxymethyl-2(5H)-furanone used as a chiral precursor.