157605-25-9

Basic information

• Product Name: alatrofloxacin
• Synonyms: L-Alanyl-N-(3-(6-carboxy-8-(2,4-difluorophenyl)-3-fluoro-5,8-dihydro-5-oxo-1,8-naphthridin-2-yl)-3-azabicyclo(3.1.0)hex-6-yl)-L-alaninamide (1alpha,5alpha,6alpha)-, monomethanesulfonate;Trovan preservative free;Trovan-iv;Unii-2ixx802851;Alatrofloxacin mesylate [usan];Cp 116,517;L-Alaninamide, L-alanyl-N-(3-(6-carboxy-8-(2,4-difluorophenyl)-3-fluoro-5,8-dihydro-5-oxo-1,8-naphthridin-2-yl)-3-azabicyclo(3.1.0)hex-6-yl)-, (1alpha,5alpha,6alpha)-, monomethanesulfonate
• CAS NO: 157605-25-9
• Molecular Formula: C27H29F3N6O8S
• Molecular Weight: 654.6147696
• Mol File: 157605-25-9.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 970.6 °C at 760 mmHg
• Flash Point: 540.8 °C
• Appearance: /
• Vapor Pressure: 0mmHg at 25°C
• CAS DataBase Reference: alatrofloxacin(CAS DataBase Reference)
• NIST Chemistry Reference: alatrofloxacin(157605-25-9)
• EPA Substance Registry System: alatrofloxacin(157605-25-9)

Safety Data

• Hazardous Substances Data: 157605-25-9(Hazardous Substances Data)

Usage

Description

Trovafloxacine mesylate, a new fluoroquinolone, was launched in Switzerland and the US, in both oral (Trovan) and iv (alatrofloxacin, N-Ala-Ala substituted prodrug of trovafloxacin) formulations for adult use as broadspectrum antibiotic agent in diverse acute bacterial infections, particularly community-acquired respiratory infections (ie nocosomial pneumonia). In a clinical study of acute exacerbations of chronic bronchitis, trovafloxacin at 100 or 200 mg daily demonstrated advantages over amoxicillin, cephalosporins and clarithromycin. A favorable pharmacokinetic profile allows only once a day dosing.

Originator

Pfizer (US)

Uses

Antibacterial.

InChI:InChI=1/C26H25F3N6O5.CH4O3S/c1-10(30)24(37)31-11(2)25(38)32-20-14-7-34(8-15(14)20)23-18(29)6-13-21(36)16(26(39)40)9-35(22(13)33-23)19-4-3-12(27)5-17(19)28;1-5(2,3)4/h3-6,9-11,14-15,20H,7-8,30H2,1-2H3,(H,31,37)(H,32,38)(H,39,40);1H3,(H,2,3,4)/t10-,11-,14-,15+,20+;/m0./s1