157634-02-1

Basic information

• Product Name: 2-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: N-BOC-2-FORMYLPIPERIDINE;2-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-BOC-2-PIPERIDINECARBALDEHYDE;1-N-Boc-2-piperidinecarboxaldehyde;N-BOC-PIPERIDINE-2-ALDEHYDE;1-Piperidinecarboxylic acid, 2-formyl-, 1,1-dimethylethyl ester;1-N-BOC-2-PIPERIDINECARBALDEHYDE;tert-butyl 2-formyltetrahydro-1(2H)-pyridinecarboxylate
• CAS NO: 157634-02-1
• Molecular Formula: C₁₁H₁₉NO₃
• Molecular Weight: 213.27
• Product Categories: pharmacetical;Piperidine
• Mol File: 157634-02-1.mol
• Article Data: 40

Chemical Properties

• Boiling Point: 85-86°/0.06mm
• Flash Point: 132.472 °C
• Appearance: /
• Density: 1.115 g/cm³
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: -2.97±0.40(Predicted)
• CAS DataBase Reference: 2-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(157634-02-1)
• EPA Substance Registry System: 2-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(157634-02-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 157634-02-1(Hazardous Substances Data)

Usage

General Description

2-FORMYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is a chemical compound with the molecular formula C12H19NO3. It is a tert-butyl ester derivative of 2-formylpiperidine-1-carboxylic acid, and is used in the pharmaceutical industry as an intermediate in the synthesis of various compounds. Its main application is in the production of pharmaceuticals and other organic compounds, where it serves as a building block for the synthesis of more complex molecules. It is also used in research and development and in chemical synthesis processes. This chemical is primarily utilized for its ability to serve as a precursor in the preparation of many biologically active compounds, making it an important component in the pharmaceutical and chemical industries.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 3433-37-2 piperidin-2-ylmethanol 
• 75844-69-8 t-butyl piperidinecarboxylate 
• 24608-52-4 tert-butyl chloroformate 
• 32559-18-5 methyl piperidine-2-carboxylate hydrochloride 
• 110-89-4 piperidine 
• 4043-87-2 pipecolic Acid 
• 98303-20-9 1-(tert-butoxycarbonyl)piperidine-2-carboxylic acid 
• 211310-10-0 2-(methoxy-N-methylcarbamoyl)piperidine-1-carboxylic acid tert-butyl ester 
• 157634-00-9 tert-butyl 2-(hydroxymethyl)piperidine-1-carboxylate 
• 68-12-2 N,N-dimethyl-formamide 
• 132910-79-3 (+/-) methyl N-tert-butyloxycarbonyl 2-piperidinecarboxylate 

Downstream Products

• 255864-58-5 tert-butyl 2-ethynylpiperidine-1-carboxylate 
• 877078-73-4 tert-butyl 2-((1S,2S)-2-(3,5-difluorobenzyl)-3-((s)-4-benzyl-2-oxooxazolidin-3-yl)-1-hydroxy-3-oxopropyl)piperidine-1-carboxylate 
• 51785-23-0 2-(piperidin-2-yl)-1H-benzo[d]imidazole 
• 1346672-96-5 3,4,6,7,8,9-hexahydropyrido[3,4-b]indolizin-1(2H)-one 
• 36067-99-9 2-benzyl-octahydro-pyrido[1,2-a]pyrazine 

Relevant articles and documents

A One-Pot Iodo-Cyclization/Transition Metal-Catalyzed Cross-Coupling Sequence: Synthesis of Substituted Oxazolidin-2-ones from N-Boc-allylamines

A one-pot iodo-cyclization/transition metal-catalyzed cross-coupling sequence is reported to access various C5-functionalized oxazolidin-2-ones from unsaturated N-Boc-allylamines. Depending on the Grignard reagents used for the cross-coupling, e.g., aryl- or cyclopropylmagnesium bromide, a cobalt or copper catalyst has to be used to obtain the functionalized oxazolidin-2-ones in good yields.

SUBSTITUTED AMINO TRIAZOLES USEFUL AS HUMAN CHITINASE INHIBITORS

Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.

PROCESS FOR MAKING TRICYCLIC LACTAM COMPOUNDS

Processes are described for the preparation of tricyclic lactam compound of Formula (I), having the structure and intermediates useful for the preparation of (I).