157640-14-7

Basic information

• Product Name: 1,2-Benzisoxazol-6-amine,3-methyl-(9CI)
• Synonyms: 1,2-Benzisoxazol-6-amine,3-methyl-(9CI);3-Methylbenzo[d]isoxazol-6-aMine
• CAS NO: 157640-14-7
• Molecular Formula: C₈H₈N₂O
• Molecular Weight: 148.16192
• Product Categories: AMINEPRIMARY
• Mol File: 157640-14-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 1,2-Benzisoxazol-6-amine,3-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Benzisoxazol-6-amine,3-methyl-(9CI)(157640-14-7)
• EPA Substance Registry System: 1,2-Benzisoxazol-6-amine,3-methyl-(9CI)(157640-14-7)

Safety Data

• Hazardous Substances Data: 157640-14-7(Hazardous Substances Data)

Usage

General Description

1,2-Benzisoxazol-6-amine,3-methyl-(9CI) is an organic compound with the molecular formula C9H9N3O. It is a derivative of benzisoxazole, a heterocyclic compound containing both benzene and isoxazole rings. This chemical is also known as 3-methyl-1,2-benzisoxazol-6-amine or 3-methylbenzo[d]isoxazol-6-amine. It is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. The compound has a range of potential applications in the research and development of novel drug molecules and molecular probes due to its diverse biological activities. However, it is important to handle this compound with care, as it may pose health hazards if not used properly.

Upstream product

• 117933-03-6 6-fluoro-3-methyl-1,2-benzisoxazole 
• 145508-92-5 6-acetamido-3-methyl-1,2-benzisoxazole 
• 62572-86-5 1-(2,4-dinitrophenyl)ethanone 
• 157640-13-6 4-acetamido-2-hydroxyacetophenone oxime acetate 

Downstream Products

• 945526-04-5 (3-methyl-benzo[d]isoxazol-6-yl)-carbamic acid benzyl ester 
• 145509-02-0 6-benzamido-3-methyl-1,2-benzisoxazole 
• 145509-03-1 4-[2-(6-Benzoylamino-benzo[d]isoxazol-3-yl)-ethyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 145509-05-3 4-[2-(6-Benzenesulfonylamino-benzo[d]isoxazol-3-yl)-ethyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 145509-04-2 6-benzenesulfonamido-3-methyl-1,2-benzisoxazole 

Relevant articles and documents

Nucleophilic aromatic substitution of unactivated fluoroarenes enabled by organic photoredox catalysis

Nucleophilic aromatic substitution (SNAr) is a classical reaction with well-known reactivity toward electron-poor fluoroarenes. However, electron-neutral and electron-rich fluoro(hetero)arenes are considerably underrepresented. Herein, we present a method for the nucleophilic defluorination of unactivated fluoroarenes enabled by cation radical-accelerated nucleophilic aromatic substitution. The use of organic photoredox catalysis renders this method operationally simple under mild conditions and is amenable to various nucleophile classes, including azoles, amines, and carboxylic acids. Select fluorinated heterocycles can be functionalized using this method. In addition, the late-stage functionalization of pharmaceuticals is also presented. Computational studies demonstrate that the site selectivity of the reaction is dictated by arene electronics.

ANTIBACTERIAL AGENTS

The present invention provides a compound of Formula (I) Or a pharmaceutically acceptable salt thereof wherein: W is CH2NHC(=Z)R1, C(=Z)NHR2, or CH2het; X is H, C1-6alkyl, or C2-6alkenyl; Y is H, or F; Z is O, or S; R1 is C1-6alkyl, NHC1-6alkyl, C3-7cycloalkyl, C2-6alkenyl, or OC1-4alkyl; R2 is H, C1-4alkyl, or -OC1-4alkyl; and het is a five-(5) or six-(6) membered heterocyclic ring having 1-4 heteroatoms selected from the group consisting of oxygen, sulfur, and nitrogen within the ring, wherein each carbon atom in het is optionally substituted with C1-4alkyl, C2-4alkenyl, C2-4alkynyl, halo, OR3, CN, NO2, NHR3R3, oxo, CF3, OCF3, C(=O)C1-4alkyl, OC(=O)C1-4alkyl, or C(=O)OR3; wherein R3 is H, or C1-4alkyl.