157642-26-7Relevant academic research and scientific papers
Determination of the Enantiomeric Excesses of Chiral Acids by 19F NMR Studies of their Esters deriving from (R)-(+)-2-(Trifluoromethyl)benzhydrol
Brown, Eric,Chevalier, Christelle,Huet, Francois,Grumelec, Christelle Le,Leze, Antoine,Touet, Joel
, p. 1191 - 1194 (2007/10/02)
15-Chiral acids were esterified with optically pure (R)-(+)-2-(trifluoromethyl)benzhydrol (R)-(+)-1, a readily available reagent.With respect to the carboxy group, the stereogenic centre is in the β-position in the case of the acids 5a-10a and 12a-16a, and in the α position in the case of the acids 17a-20a.The diastereomeric excesses of the corresponding esters 5b-10b and 12b-20b, respectively, were easily determined by means of 19F NMR.These d.e. values were in very good agreement with the e.e. values of the corresponding acids when the latter were known compounds.
Saponification agents. 2. Synthesis of arylisocyanates with ethyl lactate and their use in racemic bases saponification
Brown,Moudachirou
, p. 10309 - 10320 (2007/10/02)
Reaction of the arylisocyanates 2a-c with ethyl (S)-(-)-lactate, followed by careful saponification, afforded the corresponding chiral acids (S)-(-)- 4a-c. The latter were successfully used for the resolution of various racemic bases belonging to both the ephedrine and α-aryl ethylamine series.
