157643-41-9

Basic information

• Product Name: 2-Aziridinepropanoicacid,2-carboxy-(9CI)
• Synonyms: 2-Aziridinepropanoicacid,2-carboxy-(9CI)
• CAS NO: 157643-41-9
• Molecular Formula: C6H9NO4
• Molecular Weight: 159.13996
• Product Categories: CARBOXYLICACID
• Mol File: 157643-41-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 413.2±30.0 °C(Predicted)
• Appearance: /
• Density: 1.464±0.06 g/cm3(Predicted)
• PKA: 2.27±0.20(Predicted)
• CAS DataBase Reference: 2-Aziridinepropanoicacid,2-carboxy-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Aziridinepropanoicacid,2-carboxy-(9CI)(157643-41-9)
• EPA Substance Registry System: 2-Aziridinepropanoicacid,2-carboxy-(9CI)(157643-41-9)

Safety Data

• Hazardous Substances Data: 157643-41-9(Hazardous Substances Data)

Upstream product

• 73800-89-2 (fluoromethyl)glutamic acid 

Relevant articles and documents

The Synthesis and Stability of Aziridino-glutamate, an Irreversible Inhibitor of Glutamate Racemase

Aziridino-glutamate (2-(2-carboxyethyl)aziridine-2-carboxylic acid, (+/-)4 was synthesized by heating α-fluoromethylglutamate in base.In neutral solution, 4 was shown to cyclize to the γ-lactone 5 with a half life of 4 minutes.Aziridino-glutamate was shown to irreversibily inactivate glutamate racemase by alkylating an active site cystein residue.Electrospray mass spectrometry was used to establish that a covalent bond had formed and that this bond protects one the enzyme's two cysteine residues from reacting with iodoacetate under denaturing conditions.