157670-28-5

Usage

Uses

Used in Organic Synthesis:
Pyridine, 2-chloro-5-ethenyl(9CI) is used as a solvent in organic synthesis for facilitating various chemical reactions. Its ability to dissolve a wide range of organic compounds and its compatibility with different reaction conditions make it a valuable asset in the synthesis of complex organic molecules.
Used in Pharmaceutical Manufacturing:
Pyridine, 2-chloro-5-ethenyl(9CI) is employed as a reagent in the production of pharmaceuticals. Its presence in the synthesis process can contribute to the formation of specific drug molecules, making it an essential component in the development of new medications.
Used in Pesticide Production:
Pyridine, 2-chloro-5-ethenyl(9CI) is utilized in the manufacturing of pesticides. Its chemical properties allow it to be incorporated into the formulation of various pest control agents, helping to enhance their effectiveness in protecting crops and controlling pests.
Used in Dye Manufacturing:
Pyridine, 2-chloro-5-ethenyl(9CI) is also used in the production of dyes. Its chemical structure enables it to impart color to various materials, making it a useful component in the creation of a wide range of dyes for different applications.
Health and Safety Considerations:

Upstream product

• 5326-23-8 6-Chloro-3-pyridinecarboxylic acid 
• 23100-12-1 6-chloronicotinylaldehyde 
• 27200-84-6 methyl triphenylphosphonium bromide 
• 53939-30-3 5-bromo-2-chloropyridine 
• 75927-49-0 pinacol vinylboronate 
• 69045-79-0 2-choro-5-iodopyridine 
• 7486-35-3 tri-n-butyl(vinyl)tin 
• 1779-49-3 Methyltriphenylphosphonium bromide 

Downstream Products

• 157670-30-9 6-(6-Chloro-pyridin-3-yl)-cyclohex-2-enol 
• 157670-34-3 5-(6-Chloro-pyridin-3-yl)-cyclohex-2-enol 

Relevant academic research and scientific papers

BENZYLAMINOPYRIDYLCYCLOPROPANECARBOXYLIC ACIDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

The present invention relates to compounds of general formula (I) wherein the groups R, R1, R2, R3, m and n are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula (I).

A 2 - chloro - 5 - ethyl pyridine preparation method (by machine translation)

The invention discloses a method for synthesizing 2 - chloro - 5 - ethyl pyridine method, by Suzuki reaction with 2 - chloro - 5 - bromo pyridine or by Wittig reaction with 2 - chloro - 5 - formyl pyridine is converted into 2 - chloro - 5 - vinyl pyridine; further uses the type (I) selective hydrogenation catalyst-containing structure, wherein R is cyclohexyl, butyl or phenyl, L is pyridine or unsaturated including nitrogen Cabeen, the 2 - chloro - 5 - vinyl pyridine is converted into 2 - chloro - 5 - ethyl pyridine. The method of the invention has a high selectivity, high yield and the advantage of convenient purification. (by machine translation)

TRICYCLIC GUANIDINE DERIVATIVE

Disclosed are compounds useful as inhibitors of Phosphodiesterase 1 (PDE1), compositions thereof, and methods of using the same.

Lewis basicity modulation of N-heterocycles: A key for successful cross-metathesis

Cross-metathesis involving N-heteroaromatic olefinic derivatives is disclosed. The introduction of an appropriate substituent on the heteroaromatic ring decreases the Lewis basicity of the nitrogen atom, thus preventing the deactivation of the ruthenium-centered catalyst. The reaction is quite general in terms of both N-heterocycles and olefinic partners.

Sulfamide derivatives useful as beta3 agonists and pharmaceutical uses thereof

Sulfamide compounds having formula (I) are described as well as their use in the treatment of diseases dependent on the signaling pathways associated with β-adrenergic receptors, such as obesity, diabetes, hypertension, gastrointestinal hypo- or hyper-motility and cardiovascular diseases.

Process for preparing substituted pyridines

A process for preparing a compound of the formula wherein n, R1, R2, R3 and X are as defined above, used as an intermediate in the synthesis of P-adrenergic receptor agonists.

Beta3 agonists and uses thereof

Sulfamide compounds having formula (I) are described as well as their use in the treatment of diseases dependent on the signaling pathways associated with β-adrenergic receptors, such as obesity, diabetes, hypertension, gastrointestinal hypo- or hyper-mot

Process for preparing substituted pyridines

A process for preparing a compound of the formula wherein n, R1, R2, R3 and X are as defined above, used as an intermediate in the synthesis of β-adrenergic receptor agonists.

Process for the preparation of epibatidine

A novel 6-chloro-3-vinyl-pyridine of formula STR1 where X represents -H, -SO2 Ph, -CO2 Et, -COCH3 and -CHO; which is used for the synthesis of Epibatidine of formula STR2 by reacting said 6-chloro-3-vinyl pyridine with N-1-alkyl-2,5-di(trialkyl silyl) pyrrolidine of formula STR3 to obtain N-alkyl Epibatidine which is hydrogenated to obtain the Epibatidine.

The Total Synthesis of Epibatidine

The synthesis of the potent analgesic alkaloid epibatidine 1, employing as the key step a singlet oxygen reaction with 1-(2-chloro-5-pyridyl)cyclohexa-2,4-diene 2, is described.