157672-01-0

Basic information

• Product Name: 3-Bromo-4-(4-methylsulfanyl-phenyl)-thiophene
• Synonyms: 3-Bromo-4-(4-methylsulfanyl-phenyl)-thiophene
• CAS NO: 157672-01-0
• Molecular Weight: 285.228
• Mol File: 157672-01-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Bromo-4-(4-methylsulfanyl-phenyl)-thiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-4-(4-methylsulfanyl-phenyl)-thiophene(157672-01-0)
• EPA Substance Registry System: 3-Bromo-4-(4-methylsulfanyl-phenyl)-thiophene(157672-01-0)

Safety Data

• Hazardous Substances Data: 157672-01-0(Hazardous Substances Data)

Upstream product

• 3141-26-2 3,4-dibromothiophene 
• 98546-51-1 (4-thiomethoxyphenyl)boronic acid 

Downstream Products

• 157671-69-7 3-(4-methylsulfonylphenyl)-4-(4-fluorophenyl)-thiophene 
• 157671-73-3 3-(4-methylsulfonylphenyl)-4-(4-methoxyphenyl)-thiophene 
• 157671-94-8 3-(4-methylthiophenyl)-4-(4-methoxyphenyl)thiophene 

Relevant articles and documents

Chemistry and pharmacokinetics of diarylthiophenes and terphenyls as selective COX-2 inhibitors

DuP697, 2-bromo-4-(4'-sulfonylmethyl)phenyl-5-(4'-fluoro)phenylthiophene, is a selective type 2 cyclooxygenase (COX-2) inhibitor. Its relatively weak COX-2 selectivity coupled with a poor human pharmacokinetic profile led us to seek improvements on the in vitro selectivity while at the same time, addressing some of its pharmacokinetic liabilities. In this paper we discuss some strategies at solving the PK issue within a class of COX-2 inhibitors. The result of these efforts led to the discovery of a new class of COX-2 inhibitors the terphenyls, which prove to be superior alternatives to the diarylthiophenes.