15771-25-2

Basic information

• Product Name: 1,4-Benzenedicarboxamide,N1,N4-bis(phenylmethyl)-
• Synonyms: 1,4-Benzenedicarboxamide,N,N'-bis(phenylmethyl)- (9CI); Terephthalamide, N,N'-dibenzyl- (8CI);N,N'-Dibenzylterephthalamide; NSC 110319
• CAS NO: 15771-25-2
• Molecular Formula: C22H20 N2 O2
• Molecular Weight: 344.4064
• Mol File: 15771-25-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1,4-Benzenedicarboxamide,N1,N4-bis(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Benzenedicarboxamide,N1,N4-bis(phenylmethyl)-(15771-25-2)
• EPA Substance Registry System: 1,4-Benzenedicarboxamide,N1,N4-bis(phenylmethyl)-(15771-25-2)

Safety Data

• Hazardous Substances Data: 15771-25-2(Hazardous Substances Data)

Usage

Chemical Category

Benzene derivatives

Physical Appearance

White powder

Molecular Weight

452.52 g/mol

Industrial Applications

Intermediate in the production of polymers and resins

Use as Processing Aid

Rubber and plastics

Function

Crosslinking agent for organic polymers

Additional Applications

Processing aid in paper and textile production

Safety Precautions

Strict handling and storage guidelines to minimize risks to human health and the environment

Upstream product

• 100-20-9 terephthaloyl chloride 
• 100-46-9 benzylamine 
• 100-21-0 terephthalic acid 
• 624-38-4 para-diiodobenzene 
• 199620-14-9 chromium⁽⁰⁾ hexacarbonyl 
• 589-29-7 p-xylylene glycol 
• 101008-15-5 1,1'-(1,4-phenylenedicarbonyl)bis-(1H-1,2,3-benzotriazole) 

Downstream Products

• 808770-50-5 3,10-dibenzyl-3,10-diaza-bicyclo[10.2.2]hexadeca-1⁽¹⁵⁾,12⁽¹⁶⁾,13-triene-5,7-diyne-2,11-dione 
• 808770-45-8 N,N'-dibenzyl-N,N'-dipropargylterephthalamide 

Relevant articles and documents

Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli

In Gram-negative bacteria, efflux pumps are able to prevent effective cellular concentrations from being achieved for a number of antibiotics. Small molecule adjuvants that act as efflux pump inhibitors (EPIs) have the potential to reinvigorate existing antibiotics that are currently ineffective due to efflux mechanisms. Through a combination of rigorous experimental screening and in silico virtual screening, we recently identified novel classes of EPIs that interact with the membrane fusion protein AcrA, a critical component of the AcrAB-TolC efflux pump in Escherichia coli. Herein, we present initial optimization efforts and structure-activity relationships around one of those previously described hits, NSC 60339 (1). From these efforts we identified two compounds, SLUPP-225 (17h) and SLUPP-417 (17o), which demonstrate favorable properties as potential EPIs in E. coli cells including the ability to penetrate the outer membrane, improved inhibition of efflux relative to 1, and potentiation of the activity of novobiocin and erythromycin.

An efficient N-heterocyclic carbene based ruthenium-catalyst: Application towards the synthesis of esters and amides

A highly stable benzimidazolylidene based N-heterocyclic carbene (NHC) ruthenium catalyst was prepared starting with readily accessible starting materials. Under inert gas atmosphere and in air the catalyst showed high activity for the direct synthesis of esters from primary alcohols and of amides from primary alcohols and amines. Di-, tri-, and oligo-amides were obtained by using specific starting materials.

[10]Paracyclophanediamides and their octadehydro derivatives: Novel exotopic receptors with hydrogen-bonding sites on the bridge

2,9-Diaza-1,10-dioxo[10]paracyclophanes were prepared in short steps from the terephthaloyl chlorides via the corresponding 4,6-diyne derivatives, and the amide groups on the bridge endow the skeleton with the guest-binding properties as demonstrated by c