1577232-57-5Relevant academic research and scientific papers
Palladium-catalyzed imidoylative cyclization of α-isocyanoacetamides: Efficient access to c2-diversified oxazoles
Wang, Jian,Luo, Shuang,Huang, Jinbo,Mao, Tingting,Zhu, Qiang
, p. 11220 - 11224 (2014)
A novel procedure for the synthesis of C2-diversified oxazoles, through palladium-catalyzed imidoylative cyclization of α-isocyanoacetamides with aryl, vinyl, alkynyl halides, or triflates, was developed. Migratory insertion of isocyanide into a C sp 3-palladium(II) intermediate in a cascade process was also realized, generating alkyl-substituted oxazoles. Therefore, oxazoles functionalized at the C2 position with sp, sp2, and sp3 hybridized carbon atoms are accessible by applying this method.
Convenient one-step construction of yne-functionalized aryl halides through domino cyclization from tetraynes
Zhang, Hao,Hu, Qiong,Li, Lidong,Hu, Yimin,Zhou, Pingping,Zhang, Xiaorong,Xie, Haifeng,Yin, Fei,Hu, Yadong,Wang, Shaowu
supporting information, p. 3335 - 3337 (2014/03/21)
An efficient method for the construction of fused yne-substituted aryl halides by reaction of unactivated linear tetraynes with allyl halides via domino C-C coupling and formation of C-X bonds in the presence of Pd(OAc) 2/PPh3 was de
