1577232-57-5Relevant articles and documents
Palladium-catalyzed imidoylative cyclization of α-isocyanoacetamides: Efficient access to c2-diversified oxazoles
Wang, Jian,Luo, Shuang,Huang, Jinbo,Mao, Tingting,Zhu, Qiang
, p. 11220 - 11224 (2014)
A novel procedure for the synthesis of C2-diversified oxazoles, through palladium-catalyzed imidoylative cyclization of α-isocyanoacetamides with aryl, vinyl, alkynyl halides, or triflates, was developed. Migratory insertion of isocyanide into a C sp 3-palladium(II) intermediate in a cascade process was also realized, generating alkyl-substituted oxazoles. Therefore, oxazoles functionalized at the C2 position with sp, sp2, and sp3 hybridized carbon atoms are accessible by applying this method.