1577232-64-4

Upstream product

• 910311-11-4 4,4-di(isopropanoloxycarbonyl)-1,6-heptadiyne 
• 33491-03-1 1-(bromoethynyl)-4-chlorobenzene 
• 13195-64-7 diisopropyl malonate 

Downstream Products

• 1577232-52-0 dimethyl 7-bromo-5-phenyl-4-(phenylethynyl)-1H-indene-2,2(3H)-dicarboxylate 

Relevant academic research and scientific papers

Fully Substituted Conjugate Benzofuran Core: Multiyne Cascade Coupling and Oxidation of Cyclopropenone

An unprecedented C═C double bond cleavage of cyclopropenone and dioxygen activation by multiyne cascade coupling has been developed. This chemistry provides a novel, simple, and efficient approach to synthesize fully substituted conjugate benzofuran derivatives from simple substrates under mild conditions. The density functional theory (DFT) calculations reveal that the unique homolytic cleavages of cyclopropenone and molecular oxygen are crucial to the success of this reaction.

Polysubstituted naphthalene derivative and preparation method thereof

The invention discloses a polysubstituted naphthalene derivative and a preparation method thereof. The preparation method comprises the following steps: with a tetrayne compound and phenylacetylene asraw materials, conducting reacting for 12-14 hours at 1

Dodecahydrobenzodiindanophenanthrene derivatives and synthesis method thereof

The invention discloses dodecahydrobenzodiindanophenanthrene derivatives and a synthesis method thereof. Compared with the prior art, the invention provides a series of novel benzodiindanophenanthrenederivatives. Compared with the ordinary benzodiindanophenanthrene derivative, the benzodiindanophenanthrene derivatives prepared by the synthesis method provided by the invention have the advantagesas follows: due to existence of multiple rings, the benzodiindanophenanthrene derivatives are more complex and diverse in structure; the benzodiindanophenanthrene derivatives can be prepared into a variety of medicines, can be applied to synthetic resin, plant growth hormones, vat dyes, tanning materials and the like, and also show a brighter application prospect in chemical production; in addition, a preparation method provided by the invention is simple, convenient, short in reaction time and high in efficiency.

2H pyrane cycloquinoline ring derivative and synthesis method thereof

The invention provides a 2H pyrane cycloquinoline ring derivative and a synthesis method thereof. Compared with the prior art, the invention provides a series of new 2H pyrane cycloquinoline ring derivatives. Compared with common 2H pyrane cycloquinoline ring derivative, the 2H pyrane cycloquinoline ring derivative prepared through the method provided by the invention contains multiple rings and is more complicated and diversified in structure; during chemical production, the 2H pyrane cycloquinoline ring derivative shows wider application prospect; meanwhile, the preparation method disclosed by the invention is simple, convenient and efficient and has short reaction time and high efficiency.

The second aryl residue selenium ether derivatives and its preparation method (by machine translation)

The invention relates to the field of organic synthesis, and more particularly relates to a two-aryl residue selenium ether derivatives and its preparation method. The present invention provides a new series of two aryl residue selenium ether derivatives to the ordinary selenium ether derivatives in the presence of a multi-ring, its structure is more complex and diverse, application prospect. The preparation method comprises the following steps: in oxygen free system, the two alkyne class compounds, alkyl alkyne bromine, anhydrous acetonitrile, transition metal catalyst and organic alkali mixing and reaction intermediates. In the 90 - 100 °C conditions, intermediate, diphenyl diselenides and toluene mixed reaction. The preparation method of the substrate not only simple to synthesize, reagent is inexpensive, and has high atom economy, environmental protection obtain the target molecule, to the second aryl residue selenium ether derivatives for industrial production of a very valuable way. (by machine translation)

Benzofuran derivative and preparation method thereof

The invention discloses a benzofuran derivative and a preparation method thereof. A benzofuran compound is prepared from different multi-alkyne substrates by a cascade reaction. The reaction overcomes the defects of excessively long path, harsh substrate

Acyl chloride and alkyne addition product and preparing method thereof

The invention discloses an acyl chloride and alkyne addition product and a preparing method thereof. The preparing method includes the steps that sodium hydride is used as a catalyst, diisopropyl malonate and propargyl bromide are added into anhydrous acetonitrile, the mixture is put in an ice-water bath and stirred for reacting, and a white solid product is obtained after purification and separation; the product phenyl ethynyl bromide is mixed in an anhydrous oxygen-free catalytic system of Pd(PPh3)2Cl2/CuI, triethylamine is used as alkali, anhydrous acetonitrile is used as solvent, a light brown solid product is obtained through stirring reacting at the room temperature as well as purification and separation, the light brown solid product reacts with adamantanecarbonyl-chloride in methylbenzene, and the acyl chloride and alkyne addition product is obtained through purification and separation. Compared with the prior art, the prepared beta-chloro-alpha, beta unsaturated ketone does not need a metal catalyst, is high in yield and more complex and verified in structure and will show broader application prospects in chemical industry production and clinic medicine.

Convenient one-step construction of yne-functionalized aryl halides through domino cyclization from tetraynes

An efficient method for the construction of fused yne-substituted aryl halides by reaction of unactivated linear tetraynes with allyl halides via domino C-C coupling and formation of C-X bonds in the presence of Pd(OAc) 2/PPh3 was de