1577232-99-5

Basic information

• Product Name: 2,2-difluoro-2-(isoquinolin-7-yl)-1-phenylethanone
• Synonyms: 2,2-difluoro-2-(isoquinolin-7-yl)-1-phenylethanone
• CAS NO: 1577232-99-5
• Molecular Weight: 283.277
• Mol File: 1577232-99-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,2-difluoro-2-(isoquinolin-7-yl)-1-phenylethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-difluoro-2-(isoquinolin-7-yl)-1-phenylethanone(1577232-99-5)
• EPA Substance Registry System: 2,2-difluoro-2-(isoquinolin-7-yl)-1-phenylethanone(1577232-99-5)

Safety Data

• Hazardous Substances Data: 1577232-99-5(Hazardous Substances Data)

Upstream product

• 58794-09-5 7-bromoisoquinoline 
• 395-01-7 2,2-difluoro-1-phenylethanone 

Relevant articles and documents

Pd-catalyzed α-arylation of α,α-difluoroketones with aryl bromides and chlorides. A route to difluoromethylarenes

We report the Pd-catalyzed α-arylation of α,α- difluoroketones with aryl and heteroaryl bromides and chlorides catalyzed by an air- and moisture-stable palladacyclic complex containing P(t-Bu)Cy2 as ligand. The combination of this Pd-catalyzed arylation and base-induced cleavage of the acyl-aryl C-C bond within the α-aryl-α,α- difluoroketone constitutes a one-pot, two-step procedure to synthesize difluoromethylarenes from aryl halides. A broad range of electronically varied aryl and heteroaryl bromides and chlorides underwent these two transformations, providing α-aryl-α,α-difluoroketones, difluoromethylarenes, and difluoromethylheteroarenes in high yields.