1577233-08-9

Basic information

• Product Name: 1-(difluoromethyl)-2-isopropyl-benzene
• Synonyms: 1-(difluoromethyl)-2-isopropyl-benzene
• CAS NO: 1577233-08-9
• Molecular Weight: 170.202
• Mol File: 1577233-08-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-(difluoromethyl)-2-isopropyl-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(difluoromethyl)-2-isopropyl-benzene(1577233-08-9)
• EPA Substance Registry System: 1-(difluoromethyl)-2-isopropyl-benzene(1577233-08-9)

Safety Data

• Hazardous Substances Data: 1577233-08-9(Hazardous Substances Data)

Upstream product

• 21190-34-1 (2-isopropylphenyl)methanol 
• 6502-22-3 2-isopropylbenzaldehyde 

Relevant articles and documents

Room Temperature Deoxyfluorination of Benzaldehydes and α-Ketoesters with Sulfuryl Fluoride and Tetramethylammonium Fluoride

A method for the room temperature deoxyfluorination of benzaldehydes and α-ketoesters using sulfuryl fluoride and Me4NF is described. A large scope of aryl and heteroaryl substrates is demonstrated, and this method compares favorably to other common deoxyfluorination methods for many substrates.

Preparation method of difluoromethyl aromatic hydrocarbon compound

The invention discloses a preparation method of a difluoromethyl aromatic hydrocarbon compound, which comprises the following steps: (1) in a nitrogen atmosphere, sequentially adding an aryl mono-substituted malonic acid substrate, a silver catalyst, alkali and a selective fluorine reagent into a reaction tube, adding a solvent, and reacting at corresponding temperature for 11-13 hours, wherein the molar ratio of the aryl mono-substituted malonic acid substrate to the silver catalyst to the alkali to the selective fluorine reagent is 1: (0.1-1): (0.5-5): (4-10); and (2) carrying out quenchingreaction by using 3M hydrochloric acid, and sequentially carrying out extraction, organic phase combination, washing, drying, organic phase spin-drying and purification on the reaction product to obtain the difluoromethyl aromatic hydrocarbon compound. The preparation method disclosed by the invention is simple to operate, simple and cheap in raw materials, easy in preparation, mild in conditions,good in functional group compatibility and very practical.

METAL-CATALYZED COUPLING OF ARYL AND VINYL HALIDES WITH ALPHA, ALPHA-DIFLUOROCARBONYL COMPOUNDS

The coupling of aryl, heteroaryl, and vinyl halides with α,α-difluoroketones or silyl ethers or siylenol ethers of α,α-difluoroketones and α,α-difluoroamides and esters are described. Further derivatization of the coupling products (such as ketone cleavage and Baeyer-Villiger oxidation) is also described.