157729-47-0

Upstream product

• 958-09-8 2'-deoxy-D-adenosine 
• 157729-43-6 Thiocarbonic acid O-[(2R,3S,5R)-5-(6-amino-purin-9-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-3-yl] ester O-phenyl ester 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 129835-18-3 (2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-2-(((tert-butyldiphenylsilyl)oxy)methyl)tetrahydrofuran-3-ol 
• 157729-45-8 9-[(2R,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-((E)-styryl)-tetrahydro-furan-2-yl]-9H-purin-6-ylamine 

Downstream Products

• 206982-57-2 N⁶-benzoyl-5'-O-[(tert-butyl)diphenylsilyl]-2'-deoxy-3'-de(phosphinicooxy)adenylylmethylenesulfonylmethylene-(3'->5')-3'-O-[(tert-butyl)diphenylsilyl]-2',5'-dideoxythymidine 
• 206982-59-4 N⁶-benzoyl-2'-deoxy-3'-de(phosphinicooxy)-5'-O-(4,4'-dimethoxytrityl)adenylylmethylenesulfonylmethylene-(3'->5')-2',5'-dideoxythymidine 
• 206982-58-3 N⁶-benzoyl-2'-deoxy-3'-de(phosphinicooxy)adenylylmethylenesulfonylmethylene-(3'->5')-2',5'-dideoxythymidine 
• 206982-55-0 Thioacetic acid S-[(2S,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-3-ylmethyl] ester 
• 206982-56-1 N⁶-benzoyl-9-{(3'S,4'S)-5'-O-[(tert-butyl)diphenylsilyl]-2',3'-dideoxy-3'-C-(mercaptomethyl)-β-pentofuranosyl}adenine 
• 206982-54-9 9-{(3'S,4'S)-3'-C-[(acetylthio)methyl]-5'-O-[(tert-butyl)diphenylsilyl]-2',3'-dideoxy-β-pentofuranosyl}adenine 
• 500018-88-2 benzoic acid 2-[2-({[5-(6-amino-purin-9-yl)-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-3-yl]-hydroxy-methyl}-ethoxy-phosphinoyl)-ethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 
• 206982-53-8 9-{(3'R,4'S)-5'-O-[(tert-butyl)diphenylsilyl]-2',3'-dideoxy-3'-C-(hydroxymethyl)-β-pentofuranosyl}adenine 

Relevant academic research and scientific papers

An easy access of 2',3'-dideoxy-3'-α-C-formyl-adenosine and -guanosine analogs via stereoselective C-C bond forming radical reaction

A large-scale, facile and stereoselective synthesis of 1-[5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-3-α-C-formyl-β-D-erythr o-pentofuranosyl] -adenine (7b) and -N2-isobutyrylguanine (7c) using an intermolecular radical C-C bond formation reaction is reported. The utility of these nucleosides (7b and 7c) as building blocks for antisense oligonucleosides is discussed.