157731-51-6

Basic information

• Product Name: 4-Phenyl-3-(phenylmethyl)-2-butenoic acid methyl ester
• Synonyms: 4-Phenyl-3-(phenylmethyl)-2-butenoic acid methyl ester
• CAS NO: 157731-51-6
• Molecular Weight: 266.34
• Mol File: 157731-51-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-Phenyl-3-(phenylmethyl)-2-butenoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Phenyl-3-(phenylmethyl)-2-butenoic acid methyl ester(157731-51-6)
• EPA Substance Registry System: 4-Phenyl-3-(phenylmethyl)-2-butenoic acid methyl ester(157731-51-6)

Safety Data

• Hazardous Substances Data: 157731-51-6(Hazardous Substances Data)

Upstream product

• 96-32-2 bromoacetic acid methyl ester 
• 102-04-5 1,3-Diphenylpropanone 
• 5927-18-4 trimethyl phosphonoacetate 

Downstream Products

• 120696-21-1 1-Phenyl-2-(phenylmethyl)-2-hepten-5-yn-4-one 
• 120696-36-8 (Z)-5-Ethylidene-4-phenyl-3-(phenylmethyl)-2-cyclopenten-1-one 
• 125455-70-1 (E)-5-Ethylidene-4-phenyl-3-(phenylmethyl)-2-cyclopenten-1-one 
• 120696-22-2 6-Phenyl-5-(phenylmethyl)-4-hexen-1-yn-3-one 
• 120722-16-9 5-Methylene-4-phenyl-3-(phenylmethyl)-2-cyclopenten-1-one 
• 157731-53-8 N-Methoxy-N-methyl-4-phenyl-3-(phenylmethyl)-2-butenamide 

Relevant articles and documents

A Solid-Phase Assisted Flow Approach to In Situ Wittig-Type Olefination Coupling

Described herein is the development of a continuous flow, solid-phase triphenylphosphine (PS-PPh3) assisted protocol to facilitate the in situ coupling of reciprocal pairs of halogen and carbonyl functionalised molecular pairs by a Wittig olefination within 15 mins. The protocol entails injecting a single solution (1 : 1 CHCl3 : EtOH) containing the halogenated and carbonyl-based substrates into a continuously flowing stream of CHCl3 : EtOH (1 : 1), passed through a fixed bed of K2CO3 and PS-PPh3. With advancement to the previous PS-PPh3 coupling procedures, the method employs a traditional polystyrene-based immobilisation matrix, the substrate scope of the protocol extended to substituted ketones, secondary alkyl chlorides, and an unprotected maleimide scaffold.