157764-03-9

Basic information

• Product Name: 2-Benzothiazoleacetonitrile,5-chloro-(9CI)
• Synonyms: 2-Benzothiazoleacetonitrile,5-chloro-(9CI)
• CAS NO: 157764-03-9
• Molecular Formula: C₉H₅ClN₂S
• Molecular Weight: 208.6674
• Product Categories: BENZOTHIAZOLE
• Mol File: 157764-03-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Benzothiazoleacetonitrile,5-chloro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Benzothiazoleacetonitrile,5-chloro-(9CI)(157764-03-9)
• EPA Substance Registry System: 2-Benzothiazoleacetonitrile,5-chloro-(9CI)(157764-03-9)

Safety Data

• Hazardous Substances Data: 157764-03-9(Hazardous Substances Data)

Upstream product

• 109-77-3 malononitrile 
• 1004-00-8 4-chloro-2-aminobenzenethiol 

Downstream Products

• 1452809-60-7 2-((3-(5-chlorobenzo[d]thiazol-2-yl)-5,6-dihydro-4H-cyclopenta[b]thiophen-2-ylimino)methyl)phenol 
• 1452809-61-8 3-(5-chlorobenzo[d]thiazol-2-yl)-N-((E)-3-phenylallylidene)-5,6-dihydro-4H-cyclopenta[b]thiophen-2-amine 
• 1452809-62-9 2-((3-(5-chlorobenzo[d]thiazol-2-yl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylimino)methyl)phenol 

Relevant articles and documents

Discovery and Optimization of 2 H-1λ2-Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer

Neomorphic mutations in isocitrate dehydrogenase 1 (IDH1) are oncogenic for a number of malignancies, primarily low-grade gliomas and acute myeloid leukemia. We report a medicinal chemistry campaign around a 7,7-dimethyl-7,8-dihydro-2H-1λ2-quinoline-2,5(6H)-dione screening hit against the R132H and R132C mutant forms of isocitrate dehydrogenase (IDH1). Systematic SAR efforts produced a series of potent pyrid-2-one mIDH1 inhibitors, including the atropisomer (+)-119 (NCATS-SM5637, NSC 791985). In an engineered mIDH1-U87-xenograft mouse model, after a single oral dose of 30 mg/kg, 16 h post dose, between 16 and 48 h, (+)-119 showed higher tumoral concentrations that corresponded to lower 2-HG concentrations, when compared with the approved drug AG-120 (ivosidenib).

MUTANT IDH1 INHIBITORS USEFUL FOR TREATING CANCER

Compounds of Formula I and Formula II and the pharmaceutically acceptable salts thereof are disclosed The variables A, B, Y, Z, X1, X2, R1-4 and R13-18 are disclosed herein. The compounds are useful for treating cancer disorders, especially those involving mutant IDH1 enzymes. Pharmaceutical compositions containing compounds of Formula I or Formula II and methods of treatment comprising administering compounds of Formula I and Formula II are also disclosed.

Novel cycloalkylthiophene-imine derivatives bearing benzothiazole scaffold: Synthesis, characterization and antiviral activity evaluation

A series of novel cycloalkylthiophene-imine derivatives containing benzothiazole unit were designed, synthesized and evaluated for their anti-viral activities. The bio-evaluation results indicated that some of the target compounds (such as 5g, 5i, 5u) exhibited good to moderate antiviral effect on CVB5, ADV7 and EV71 viruses, however, these compounds did not have inhibition activity against H1N1 virus. Especially, the compounds 4c and 4d also exhibited high antiviral activities, which provide a new and efficient approach to evolve novel multi-functional antiviral agents by rational integration of active pharmacophores.