157766-28-4

Basic information

• Product Name: 1,2,3,4-tetrafluoro-5-(trichloromethyl)benzene
• Synonyms: 1,2,3,4-Tetrafluoro-5-(trichloromethyl)benzene; benzene, 1,2,3,4-tetrafluoro-5-(trichloromethyl)-
• CAS NO: 157766-28-4
• Molecular Formula: C₇HCl₃F₄
• Molecular Weight: 267.4355
• Mol File: 157766-28-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 214.9°C at 760 mmHg
• Flash Point: 95.8°C
• Density: 1.697g/cm³
• Vapor Pressure: 0.223mmHg at 25°C
• Refractive Index: 1.486
• CAS DataBase Reference: 1,2,3,4-tetrafluoro-5-(trichloromethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,4-tetrafluoro-5-(trichloromethyl)benzene(157766-28-4)
• EPA Substance Registry System: 1,2,3,4-tetrafluoro-5-(trichloromethyl)benzene(157766-28-4)

Safety Data

• Hazardous Substances Data: 157766-28-4(Hazardous Substances Data)

Upstream product

• 56-23-5 tetrachloromethane 
• 551-62-2 1,2,3,4-tetrafluorobenzene 
• 654-53-5 1,2,3,4-tetrafluoro-5-(trifluoromethyl)benzene 

Downstream Products

• 94695-48-4 2,3,4,5-tetrafluorobenzoyl chloride 
• 1567382-97-1 4-amino-2,3,5-trifluorobenzonitrile 

Relevant articles and documents

Selective one-pot synthesis of aminopolyhalobenzonitriles from polyhalobenzotrichlorides in anhydrous ammonia

Polyhalogenated benzotrichlorides (pentafluoro-, chlorotetrafluoro-, chlorotrifluoro-, and tetrafluorobenzotrichlorides) undergo one-pot ammonolysis?+?aminodefluorination by the action of anhydrous ammonia to form mono- and diamino derivatives of polyhalobenzonitriles. For the substrates comprising halogen at the para-position, the ammonolysis of the CCl3 group and the first aminodefluorination occur simultaneously in the temperature range from ?33 to 5?°C. The temperature of introducing the second NH2 group is higher by 60–100?°C, whereby conditions were found for the selective synthesis of mono- and diaminopolyhalobenzonitriles. The use of anhydrous ammonia as a reagent and a solvent minimizes side reactions and simplifies an isolation of the high purity products.

Process for the preparation of nuclear-halogenated benzotrichlorides from the corresponding benzotrifluorides

Nuclear-halogenated benzotrichlorides are prepared in a particularly advantageous manner from the corresponding nuclear-halogenated benzotrifluorides by reacting nuclear-halogenated benzotrifluorides with silicon tetrachloride in the presence of catalytic amounts of aluminium trichloride.