157791-72-5Relevant academic research and scientific papers
Synthesis of Acyltrialkylgermanes and Reactions with Carbon Nucleophiles
Nishimura, Teruyuki,Inoue-Ando, Sumie,Sato, Yoshiro
, p. 1589 - 1594 (2007/10/02)
Acyltrialkylgermanes 4 have been obtained in good yields by the Swern oxidation of trialkyl(1-hydroxyalkyl)germanes 3 which were prepared from aldehydes 1 and trialkylgermyllithium 2.Reaction of 4 with butyllithium 5, tert-butyl lithioacetate 7 or 2-lithiopropionitrile 9 gave the respective 1,2-addition products 6, 8 and 10.However, reaction with 1-lithioethyl phenyl sulfone 11 gave α-(trialkylgermyl) ketones 12, and with the lithium enolate of tert-butyl bromoacetate 14 gave (trialkylgermyl)oxiranes 15 as the main products, respectively.The results of the treatment of 15 with Lewis acids are also described.
