15781-74-5

Usage

InChI:InChI=1/C22H12Cl6O4/c23-12-7-15(25)19(16(26)8-12)31-21(29)14(6-11-4-2-1-3-5-11)22(30)32-20-17(27)9-13(24)10-18(20)28/h1-5,7-10,14H,6H2

Upstream product

• 616-75-1 2-benzylmalonic acid 
• 88-06-2 2,4,6-Trichlorophenol 
• 100-44-7 benzyl chloride 
• 607-81-8 diethyl 2-benzylmalonate 

Downstream Products

• 69395-67-1 2-allylsulfanyl-6-benzyl-[1,3,4]thiadiazolo[3,2-a]pyrimidine-5,7-dione 
• 39973-86-9 2-benzyl-1-hydroxy-5-phenyl-pyrano[3,2-a]quinolizine-3,6-dione 
• 53528-87-3 6-benzyl-8-ethyl-5,7-dioxo-4,5,6,7-tetrahydro-[1,3,4]thiadiazolo[3,2-a]pyrimidinylium betaine 
• 38285-71-1 2,5-dibenzyl-1-hydroxy-benzo[4,5]oxazolo[3,2-a]pyrano[3,2-c]pyridine-3,6-dione 
• 69395-59-1 6-benzyl-2-ethylsulfanyl-[1,3,4]thiadiazolo[3,2-a]pyrimidine-5,7-dione 
• 69395-63-7 6-benzyl-2-butylsulfanyl-[1,3,4]thiadiazolo[3,2-a]pyrimidine-5,7-dione 
• 38285-63-1 2-benzyl-3-hydroxy-4-phenyl-benzo[4,5]oxazolo[3,2-a]pyridin-1-one 
• 69395-70-6 6-benzyl-2-benzylsulfanyl-[1,3,4]thiadiazolo[3,2-a]pyrimidine-5,7-dione 
• 116993-31-8 6-benzyl-7-hydroxy-2,2-dimethyl-2,3-dihydro-1H-indolizin-5-one 
• 101350-74-7 3-benzyl-1,2-dihydro-4-hydroxy-7-methyl-2-oxo-1,8-naphthyridine 
• 120537-76-0 3-benzyl-2-hydroxy-6-methyl-4-oxo-4H-pyrido<1,2-a>pyrimidine 
• 120537-80-6 6-amino-3-benzyl-2-hydroxy-4-oxo-4H-pyrido<1,2-a>pyrimidine 
• 86913-31-7 1-Acetyl-3-benzyl-2-hydroxy-4-chinolizinon 
• 94017-99-9 5-Benzyl-6-hydroxy-2-methyl-4H-imidazo<4,5,1-ij>quinolin-4-one 

Relevant academic research and scientific papers

Synthesis and insecticidal activity of mesoionic pyrido[1,2-α]pyrimidinone derivatives containing a neonicotinoid moiety

Mesoionic pyrido[1,2-α]pyrimidinone derivatives containing a neonicotinoid moiety were designed, synthesized, and evaluated for their insecticidal activity. Some of the title compounds showed remarkable insecticidal properties against Aphis craccivora. Compound I13 exhibited satisfactory insecticidal activity against A. craccivora. Meanwhile, label-free proteomics analysis of compound I13 treatment identified a total of 821 proteins. Of these, 35 proteins were up-regulated, whereas 108 proteins were down-regulated. Differential expressions of these proteins reflected a change in cellular structure and metabolism.

METHYLENE LINKED QUINOLINYL MODULATORS OF RORyt

The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.

Synthesis and reactions of 4-hydroxy-8,9,10, 11-tetrahydropyrido[3,2,1-jk] carbazol-6-ones

(Chemical Equation Presented) Tetrahydrocarbazoles 4 obtained from phenylhydrazines and cyclohexanones gave by cyclocondensation with 2-substituted malonates 5 in all cases 4-hydroxy-8,9,10,11-tetrahydropyrido [3,2,1-jk]carbazol-6-ones 6 by attack at the nitrogen and the aromatic ring of tetrahydrocarbazoles 4; the direction of the cyclization was not dependent on substituents either in the aromatic or the saturated ring; isomeric pyridocarbazoles could not be isolated. Electrophilic substitutions of pyridocarbazoles 6 under mild conditions took place exclusively at the 5-position and gave pyridocarbazolediones 9-11 with 5-nitro-, 5-hydroxy or 5-chloro-substituents. Exchange of the chloro substituent in 11 gave 5-azido- and 5-amino products 12, 14 or 16. Reactions at the aromatic ring were not observed. Chlorination of 4-hydroxypyridocarbazoles 6 with phosphoryl chloride by nucleophilic substitution took place exclusively at the 4-position and gave 4-chloropyridocarbazolones 17, which were further reacted to azides and amines 18, 19.

Malonates in cyclocondensation reactions

The use of malonates such as diethyl malonates 9, (chlorocarbonyl)ketenes 15 and bis(2,4,6-trichlorophenyl) malonates 18 as reagents for cyclocondensation with 1,3-dinucleophiles to give six-membered heterocycles is described. Further attempts to use malonates such as bis(trimethylsilyl) malonates 19 and bis(carbamimidoyl) malonates 29 as new cyclocondensation agents are described.