157810-81-6 Usage
Description
Indinavir is an HIV-1 protease inhibitor (Ki = 0.358 nM). It is selective for HIV-1 protease over HIV-2 protease (Ki = 3.316 nM), as well as human cathepsin D, porcine pepsin, bovine chymosin, human plasma renin, Factor Xa, and elastase at 10 μM. It is also selective for wild-type HIV-1 protease over the protease inhibitor-resistant mutants A-44, K-60, and V-18 (Kis = 0.24, 15, 50, and 40 nM, respectively). Indinavir is active against multiple HIV-1 variants in cell-based assays (IC95s = 12-100 nM). Formulations containing indinavir have been used in combination with antiretroviral agents in the treatment of HIV infection.
Chemical Properties
Crystalline Solid
Uses
Different sources of media describe the Uses of 157810-81-6 differently. You can refer to the following data:
1. Member of the novel hydroxyaminopentane amide class of HIV-1 protease inhibitors. Antiviral
2. Indinavir Sulfate is a member of the novel hydroxyaminopentane amide class of HIV-1 protease inhibitors. Antiviral. It is a COVID19-related research product.
Hazard
Moderately toxic by ingestion.
Check Digit Verification of cas no
The CAS Registry Mumber 157810-81-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,7,8,1 and 0 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 157810-81:
(8*1)+(7*5)+(6*7)+(5*8)+(4*1)+(3*0)+(2*8)+(1*1)=146
146 % 10 = 6
So 157810-81-6 is a valid CAS Registry Number.
