1578154-07-0Relevant articles and documents
A New Approach of Mitigating CYP3A4 Induction Led to the Discovery of Potent Hepatitis B Virus (HBV) Capsid Inhibitor with Optimal ADMET Profiles
Lin, Xianfeng,Shi, Houguang,Zhang, Weixing,Qiu, Zongxing,Zhou, Zheng,Dey, Fabian,Zhong, Sheng,Qiu, Hongxia,Xie, Jianxun,Zhou, Xue,Yang, Guang,Tang, Guozhi,Shen, Hong C.,Zhu, Wei
, p. 10352 - 10361 (2019/11/29)
Described herein is a new approach to mitigate CYP3A4 induction. In this unconventional approach, a fine-tuning of the dihedral angle between the C4 phenyl and the dihydropyrimidine core of the heteroaryldihydropyrimidine (HAP) class of capsid inhibitors
6-AMINO ACID HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
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Page/Page column 93; 111, (2014/03/26)
The invention provides novel compounds having the general formula:, wherein R1, R2, R3, R4 and A are as described herein, compositions including the compounds and methods of using the compounds.