157823-75-1

Usage

Uses

Used in Pharmaceutical Chemistry:
(R)-3-Benzyl-4-(hydroxymethyl)-2-oxazolidinone is used as a chiral reagent for the synthesis of various biologically active compounds. Its application in this industry is due to its ability to selectively catalyze asymmetric reactions, which is crucial for the development of pharmaceuticals with desired chiral properties.
Used in Organic Synthesis:
In the field of organic synthesis, (R)-3-Benzyl-4-(hydroxymethyl)-2-oxazolidinone serves as a versatile building block. It is used for the preparation of a wide range of compounds, including pharmaceuticals, agrochemicals, and other fine chemicals. (R)-3-Benzyl-4-(hydroxymethyl)-2-oxazolidinone's utility in this industry stems from its structural diversity and reactivity, which allow for the creation of complex molecular structures.
Used in Catalyst Development:
(R)-3-Benzyl-4-(hydroxymethyl)-2-oxazolidinone has also shown potential as a catalyst for the enantioselective synthesis of various optically active compounds. Its application in this area is significant because it enables the production of enantiomerically pure compounds, which are essential in many chemical and pharmaceutical processes. (R)-3-Benzyl-4-(hydroxymethyl)-2-oxazolidinone's ability to selectively promote specific reactions makes it a valuable tool in the development of efficient and selective catalysts.

Upstream product

• 3173-56-6 benzyl isothiocyanate 
• 57044-25-4 (R)-oxiranemethanol 
• 312736-44-0 carbonic acid [(S)-3-benzyl-2-oxo-oxazolidin-4-yl]methyl ester tert-butyl ester 
• 100-44-7 benzyl chloride 

Downstream Products

• 867344-14-7 (S)-3-Benzyl-2-oxo-oxazolidine-4-carboxylic acid 
• 312736-45-1 propionic acid [(R)-3-benzyl-2-oxo-oxazolidin-4-yl]methyl ester 
• 157823-80-8 (S)-3-Benzyl-4-((S)-hydroxy-phenyl-methyl)-oxazolidin-2-one 
• 157823-83-1 (S)-3-Benzyl-4-((R)-hydroxy-phenyl-methyl)-oxazolidin-2-one 
• 157823-82-0 (S)-3-Benzyl-4-((R)-1-hydroxy-ethyl)-oxazolidin-2-one 
• 157823-79-5 (S)-3-Benzyl-4-((S)-1-hydroxy-ethyl)-oxazolidin-2-one 
• 157823-81-9 Benzoic acid (R)-1-((S)-3-benzyl-2-oxo-oxazolidin-4-yl)-ethyl ester 
• 157823-78-4 (S)-4-Benzoyl-3-benzyl-oxazolidin-2-one 
• 157823-76-2 (4S)-3-benzyl-2-oxo-oxazolidine-4-carboxylic acid methyl ester 
• 157823-77-3 (S)-4-Acetyl-3-benzyl-oxazolidin-2-one 
• 68534-64-5 (1S,2S)-(+)-2-(benzylamino)-1-phenylpropane-1,3-diol 

Relevant academic research and scientific papers

INHIBITOR CONTAINING TRICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF

An inhibitor containing a tricyclic derivative, a preparation method therefor and a pharmaceutical composition comprising the inhibitor, as well as a use thereof as a phosphoinositide 3 kinase (PI3K) inhibitor in the treatment of cancer and diseases or conditions mediated by or dependent on PI3K imbalance.

Crystal form containing triple-fused-ring derivative free alkali and pharmaceutical composition thereof

The invention relates to a crystal form containing triple-fused-ring derivative free alkali and a pharmaceutical composition thereof. The invention specifically relates to a crystal form of a compound free alkali with a general formula (I), a preparation method, a pharmaceutical composition containing a therapeutically effective amount of the crystal form, and an application of the crystal form in preparation of drugs for treating PI3K-mediated related diseases.

Rearrangements and racemisation during the synthesis of L-serine derived oxazolidin-2-ones

The propensity for N-Boc-4-hydroxymethyl-oxazolidin-2-ones to undergo rapid O-O and N-O carbonyl transfer makes these L-serine derived chiral auxiliaries unsuitable for attachment to polymers.

Polymer supported oxazolidin-2-ones derived from L-serine - A cautionary tale

The capacity of N-Boc-4-hydroxymethyl-oxazolidin-2-ones to undergo rapid O-O and N-O acyl transfer makes these serine derived chiral auxiliaries unsuitable for attachment to polymers. (C) 2000 Elsevier Science Ltd.

Diastereoselective Synthesis of γ-Hydroxy-β-amino Alcohols, (2S,3S)- and (2S,3R)-Threoninol and -Hydroxyphenylalaninol, from (R)-Glycidol via the Derived 4-Hydroxymethyloxazolidinone

Syntheses of enantiomerically pure (2S,3S)- and (2S,3R)-threoninol and (2S,3R)-hydroxyphenylalaninol are demonstrated starting from (R)-glycidol via (S)-4-methoxycarbonyl-2-oxazolidinone by monoalkylation of the ester followed by diastereoselective reduct