157823-75-1

Basic information

• Product Name: (R)-3-Benzyl-4-(hydroxymethyl)-2-oxazolidinone
• Synonyms: (R)-3-Benzyl-4-(hydroxymethyl)-2-oxazolidinone
• CAS NO: 157823-75-1
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.23
• Mol File: 157823-75-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R)-3-Benzyl-4-(hydroxymethyl)-2-oxazolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-Benzyl-4-(hydroxymethyl)-2-oxazolidinone(157823-75-1)
• EPA Substance Registry System: (R)-3-Benzyl-4-(hydroxymethyl)-2-oxazolidinone(157823-75-1)

Safety Data

• Hazardous Substances Data: 157823-75-1(Hazardous Substances Data)

Usage

General Description

(R)-3-Benzyl-4-(hydroxymethyl)-2-oxazolidinone is a chemical compound that belongs to the class of oxazolidinones. It is widely used as a chiral reagent in organic synthesis and pharmaceutical chemistry due to its ability to selectively catalyze asymmetric reactions. (R)-3-Benzyl-4-(hydroxymethyl)-2-oxazolidinone has a chiral center and exists as two enantiomers, with the (R)-enantiomer being the most commonly used. It is a versatile building block in the synthesis of various biologically active compounds and has been utilized in the preparation of pharmaceuticals, agrochemicals, and other fine chemicals. Additionally, (R)-3-Benzyl-4-(hydroxymethyl)-2-oxazolidinone has also shown potential as a catalyst for the enantioselective synthesis of various optically active compounds.

Upstream product

• 3173-56-6 benzyl isothiocyanate 
• 57044-25-4 (R)-oxiranemethanol 
• 312736-44-0 carbonic acid [(S)-3-benzyl-2-oxo-oxazolidin-4-yl]methyl ester tert-butyl ester 
• 100-44-7 benzyl chloride 

Downstream Products

• 157823-80-8 (S)-3-Benzyl-4-((S)-hydroxy-phenyl-methyl)-oxazolidin-2-one 
• 157823-83-1 (S)-3-Benzyl-4-((R)-hydroxy-phenyl-methyl)-oxazolidin-2-one 
• 157823-82-0 (S)-3-Benzyl-4-((R)-1-hydroxy-ethyl)-oxazolidin-2-one 
• 157823-79-5 (S)-3-Benzyl-4-((S)-1-hydroxy-ethyl)-oxazolidin-2-one 
• 157823-81-9 Benzoic acid (R)-1-((S)-3-benzyl-2-oxo-oxazolidin-4-yl)-ethyl ester 
• 157823-78-4 (S)-4-Benzoyl-3-benzyl-oxazolidin-2-one 
• 157823-76-2 (4S)-3-benzyl-2-oxo-oxazolidine-4-carboxylic acid methyl ester 
• 157823-77-3 (S)-4-Acetyl-3-benzyl-oxazolidin-2-one 
• 68534-64-5 (1S,2S)-(+)-2-(benzylamino)-1-phenylpropane-1,3-diol 
• 312736-45-1 propionic acid [(R)-3-benzyl-2-oxo-oxazolidin-4-yl]methyl ester 
• 867344-14-7 (S)-3-Benzyl-2-oxo-oxazolidine-4-carboxylic acid 

Relevant articles and documents

INHIBITOR CONTAINING TRICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF

An inhibitor containing a tricyclic derivative, a preparation method therefor and a pharmaceutical composition comprising the inhibitor, as well as a use thereof as a phosphoinositide 3 kinase (PI3K) inhibitor in the treatment of cancer and diseases or conditions mediated by or dependent on PI3K imbalance.

Rearrangements and racemisation during the synthesis of L-serine derived oxazolidin-2-ones

The propensity for N-Boc-4-hydroxymethyl-oxazolidin-2-ones to undergo rapid O-O and N-O carbonyl transfer makes these L-serine derived chiral auxiliaries unsuitable for attachment to polymers.

Diastereoselective Synthesis of γ-Hydroxy-β-amino Alcohols, (2S,3S)- and (2S,3R)-Threoninol and -Hydroxyphenylalaninol, from (R)-Glycidol via the Derived 4-Hydroxymethyloxazolidinone

Syntheses of enantiomerically pure (2S,3S)- and (2S,3R)-threoninol and (2S,3R)-hydroxyphenylalaninol are demonstrated starting from (R)-glycidol via (S)-4-methoxycarbonyl-2-oxazolidinone by monoalkylation of the ester followed by diastereoselective reduct