1578244-28-6

Basic information

• Product Name: 1-((2-((2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)amino)-2-methylpropan-2-ol
• Synonyms: 1-((2-((2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)amino)-2-methylpropan-2-ol
• CAS NO: 1578244-28-6
• Molecular Weight: 419.486
• Mol File: 1578244-28-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-((2-((2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)amino)-2-methylpropan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-((2-((2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)amino)-2-methylpropan-2-ol(1578244-28-6)
• EPA Substance Registry System: 1-((2-((2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)amino)-2-methylpropan-2-ol(1578244-28-6)

Safety Data

• Hazardous Substances Data: 1578244-28-6(Hazardous Substances Data)

Upstream product

• 1578245-95-0 8-chloro-2-(methylsulfanyl)pyrido[3,4-d]pyrimidine 
• 1578245-94-9 2-(methylsulfanyl)-7H,8H-pyrido[3,4-d]pyrimidin-8-one 
• 1578245-93-8 methyl 5-[(E)-2-ethoxyethenyl]-2-(methylsulfanyl)pyrimidine-4-carboxylate 
• 1578244-55-9 8-chloro-N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]-pyrimidin-2-amine 
• 2854-16-2 1-Amino-2-methyl-propan-2-ol 
• 1400287-74-2 2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)aniline 
• 1578246-27-1 N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)formamide 
• 50593-91-4 methyl 5-bromo-2-(methylsulfanyl)pyrimidine-4-carboxylate 
• 1578246-63-5 8-chloro-2-(methylsulfonyl)pyrido[3,4-d]pyrimidine 

Relevant articles and documents

Expanding the scope of fused pyrimidines as kinase inhibitor scaffolds: Synthesis and modification of pyrido[3,4-d]pyrimidines

Fused pyrimidine cores are privileged kinase scaffolds, yet few examples of the 2-amino-pyrido[3,4-d]pyrimidine chemotype have been disclosed in the context of kinase inhibitor programs. Furthermore, no general synthetic route has been reported to access 2-amino-pyrido[3,4-d]pyrimidine derivatives. Here we report a versatile and efficient chemical approach to this class of molecules. Our strategy involves the concise preparation of 8-chloro-2-(methylthio)pyrido[3,4-d]pyrimidine intermediates and their efficient derivatisation to give novel compounds with potential as kinase inhibitors.