157825-35-9

Basic information

• Product Name: (R)-2-(tert-butyldiphenylsiloxymethyl)-5-methoxy-3,4-dihydro-2H-pyrrole
• Synonyms: (R)-2-(tert-butyldiphenylsiloxymethyl)-5-methoxy-3,4-dihydro-2H-pyrrole
• CAS NO: 157825-35-9
• Molecular Weight: 367.563
• Mol File: 157825-35-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-2-(tert-butyldiphenylsiloxymethyl)-5-methoxy-3,4-dihydro-2H-pyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(tert-butyldiphenylsiloxymethyl)-5-methoxy-3,4-dihydro-2H-pyrrole(157825-35-9)
• EPA Substance Registry System: (R)-2-(tert-butyldiphenylsiloxymethyl)-5-methoxy-3,4-dihydro-2H-pyrrole(157825-35-9)

Safety Data

• Hazardous Substances Data: 157825-35-9(Hazardous Substances Data)

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 66673-40-3 (R)-5-hydroxymethylpyrrolidin-2-one 
• 138629-44-4 (R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrrolidin-2-one 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 170421-36-0 Amino-[(R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-pyrrolidin-(2E)-ylidene]-acetic acid ethyl ester 
• 157825-36-0 [(R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-pyrrolidin-(2Z)-ylidene]-nitro-acetic acid ethyl ester 

Relevant articles and documents

Synthesis, Chemical Property, and Cytotoxicity of the Carzinophilin Congeners Carrying a 2-(1-Acylamino-1-alkoxycarbonyl)methylidene-1-azabicyclohexane System

Synthesis of the title compounds was achieved by employing condensation of the 2-methoxy-1-pyrroline with ethyl nitroacetate and construction of 1-azabicyclohexane systems from 5-mesyloxymethylpirrolidines as key steps.Some of these congeners which carry a C6-C11 unit involving the naphthalene part, were found to exhibit prominent cytotoxicity and effectively alkylate nucleophiles at both the aziridine and epoxide moieties. Key words: carzinophilin congeners, synthesis, chemical property, reaction with nucleophiles, cytotoxicity

Synthetic studies of carzinophilin. Part 1: Synthesis of 2-methylidene-1-azabicyclo[3.1.0]hexane systems related to carzinophilin

Synthesis of the model compounds of carzinophilin carrying 2-methylidene-1-aza-bicyclo[3.1.0]hexane systems was achieved. Formation of malonylidenes or N-acyl-glycinylidenepyrrolidines was carried out by utilizing Eschenmoser's sulfide contraction or Herdeis's condensation between the 2-methylthio-Δ1-pyrrolone derivatives and ethyl nitroacetate, respectively. The 1-azabicyclo-[3.1.0]hexane systems were constructed by base-promoted aziridine formation.