157825-35-9Relevant academic research and scientific papers
Synthesis, Chemical Property, and Cytotoxicity of the Carzinophilin Congeners Carrying a 2-(1-Acylamino-1-alkoxycarbonyl)methylidene-1-azabicyclohexane System
Hashimoto, Masaru,Matsumoto, Miyoko,Yamada, Kaoru,Terashima, Shiro
, p. 2207 - 2210 (1994)
Synthesis of the title compounds was achieved by employing condensation of the 2-methoxy-1-pyrroline with ethyl nitroacetate and construction of 1-azabicyclohexane systems from 5-mesyloxymethylpirrolidines as key steps.Some of these congeners which carry a C6-C11 unit involving the naphthalene part, were found to exhibit prominent cytotoxicity and effectively alkylate nucleophiles at both the aziridine and epoxide moieties. Key words: carzinophilin congeners, synthesis, chemical property, reaction with nucleophiles, cytotoxicity
ASK1 INHIBITOR COMPOUNDS AND USES THEREOF
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Paragraph 0510; 0512, (2018/11/02)
Described herein are compounds, including pharmaceutically acceptable salts, solvates, metabolites, prodrugs thereof, methods of making such compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat non
Synthetic studies of carzinophilin. Part 1: Synthesis of 2-methylidene-1-azabicyclo[3.1.0]hexane systems related to carzinophilin
Hashimoto, Masaru,Matsumoto, Miyoko,Terashima, Shiro
, p. 3019 - 3040 (2007/10/03)
Synthesis of the model compounds of carzinophilin carrying 2-methylidene-1-aza-bicyclo[3.1.0]hexane systems was achieved. Formation of malonylidenes or N-acyl-glycinylidenepyrrolidines was carried out by utilizing Eschenmoser's sulfide contraction or Herdeis's condensation between the 2-methylthio-Δ1-pyrrolone derivatives and ethyl nitroacetate, respectively. The 1-azabicyclo-[3.1.0]hexane systems were constructed by base-promoted aziridine formation.
