1578255-95-4Relevant academic research and scientific papers
Highly enantioselective direct Michael addition of 1,3-dicarbonyl compounds to β-fluoroalkyl-α-nitroalkenes
Zhao, Yan,Wang, Xiao-Jin,Lin, Yun,Cai, Chen-Xin,Liu, Jin-Tao
, p. 2523 - 2528 (2014)
Cinchona alkaloid catalysts were used in the Michael addition reaction of 1,3-dicarbonyl compounds to β-fluoroalkyl-α-nitroalkenes for the first time. The catalytic system performed well over a broad scope of substrates including β-keto esters and 1,3-diketones with high diastereoselectivities and excellent enantioselectivities (up to 99% ee) under mild conditions. A wide range of useful fluorinated chiral building blocks was synthesized.
