1578268-91-3Relevant academic research and scientific papers
Visible light driven metal-free intramolecular cyclization: A facile synthesis of 3-position substituted 3,4-dihydroisoquinolin-1(2: H)-one
Zou, Shuai,Geng, Shu,Chen, Lina,Wang, Haitao,Huang, Feng
, p. 380 - 387 (2019/01/10)
A visible-light metal-free photocatalytic synthesis of 3-position substituted 3,4-dihydroisoquinolin-1(2H)-one derivatives under mild conditions in moderate to good yields is described. EosinY Na, an organic dye, which is of low cost and has good availability, is used as the photocatalyst. A wide range of substrates are tolerated and the gram-scale reaction can also proceed smoothly. Mechanistic studies indicate that a plausible free radical process is proposed.
Copper(II)-Catalyzed Alkene Aminosulfonylation with Sodium Sulfinates for the Synthesis of Sulfonylated Pyrrolidones
Rao, Wei-Hao,Jiang, Li-Li,Liu, Xiao-Meng,Chen, Mei-Jun,Chen, Fang-Yuan,Jiang, Xin,Zhao, Jin-Xiao,Zou, Guo-Dong,Zhou, Yu-Qiang,Tang, Lin
, p. 2890 - 2893 (2019/04/30)
A copper-catalyzed direct aminosulfonylation of unactivated alkenes with sodium sulfinates for the efficient synthesis of sulfonylated pyrrolidones is described. This reaction features good functional group tolerance and wide substrate scope, providing an efficient and straightforward protocol to access this kind of pyrrolidones. Moreover, preliminary mechanistic investigations disclosed that a free-radical pathway might be invovled in the process.
CuX2-mediated oxybromination/aminochlorination of unsaturated amides: Synthesis of iminolactones and lactams
Zhang, Zhi-Qiang,Liu, Feng
, p. 6690 - 6693 (2015/06/25)
We report herein a CuX2-mediated halocyclization of γ,δ-unsaturated amides for the synthesis of functionalized iminolactones and lactams respectively under mild reaction conditions. Mechanism studies indicated that N-attack cyclization was via a radical route while oxycyclization was via a nucleophilic attack on the activated CC bond.
A series of two oxidation reactions of ortho-alkenylbenzamide with hypervalent iodine(III): A concise entry into (3 R,4 R)-4-hydroxymellein and (3 R,4 R)-4-hydroxy-6-methoxymellein
Takesue, Takuya,Fujita, Morifumi,Sugimura, Takashi,Akutsu, Hiroki
supporting information, p. 4634 - 4637 (2015/01/09)
A sequence of oxidation reactions of alkenamides with hypervalent iodine is described. Oxidation of ortho-alkenylbenzamide substrates selectively gave isochroman-1-imine products. The products underwent further oxidation in the presence of a Pd salt catal
Asymmetric palladium-catalyzed directed intermolecular fluoroarylation of styrenes
Talbot, Eric P. A.,Fernandes, Talita De A.,McKenna, Jeffrey M.,Toste, F. Dean
, p. 4101 - 4104 (2014/04/03)
A mild catalytic asymmetric direct fluoro-arylation of styrenes has been developed. The palladium-catalyzed three-component coupling of Selectfluor, a styrene and a boronic acid, provides chiral monofluorinated compounds in good yield and in high enantiom
