15786-31-9Relevant articles and documents
A facile electrochemical approach for the synthesis of macrocyclic alkanones
Singh, Arpita,Singhal, Nishi,Agrawal, Hemlata,Yadav, Ashok K.
, p. 423 - 426 (2007/10/03)
The synthesis of macrocyclic alkanones, viz. cyclotetradecanone 4a, cyclohexadecanone 4b, cyclooctadecanone 4c, cyclopentadecanone 4d and cycloheptadecanone 4e have been carried out by using Kolbe symmetrical/unsymmetrical dimerization followed by cyclization in Na-xylene and subsequent reduction with Zn-HCI in 70-80% yield. The products of anodic cross coupling have been separated by column chromatography over silica gel (60-120 mesh) by eluting with benzene-methanol (95: 5). An effort has been made to optimize the electrochemical step by investigating the effect of different parameters, viz. degree of partial neutralization, current density and electrode material. The products have been characterised by elemental analyses and IR and 1H NMR spectral data.