157864-30-7

Basic information

• Product Name: 3-Pyridinecarboxamide, N-[2-(aminocarbonyl)-4-nitrophenyl]-
• CAS NO: 157864-30-7
• Molecular Formula: C13H10N4O4
• Molecular Weight: 286.247
• Mol File: 157864-30-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-Pyridinecarboxamide, N-[2-(aminocarbonyl)-4-nitrophenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarboxamide, N-[2-(aminocarbonyl)-4-nitrophenyl]-(157864-30-7)
• EPA Substance Registry System: 3-Pyridinecarboxamide, N-[2-(aminocarbonyl)-4-nitrophenyl]-(157864-30-7)

Safety Data

• Hazardous Substances Data: 157864-30-7(Hazardous Substances Data)

Upstream product

• 16313-65-8 2-amino-5-nitrobenzamide 
• 20260-53-1 pyridine-3-carbonyl chloride hydrochloride 

Relevant articles and documents

Method for inhibiting neoplastic cells and related conditions by exposure to 4-aminoquinazoline derivatives

A method for inhibiting neoplastic cells and related conditions by exposing them to 4-aminoquinazoline derivatives.

Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and thromboxane synthesis inhibitory activities

Moderate cyclic GMP phosphodiesterase (cGMP-PDE, PDE V) inhibitor 2- phenyl-4-anilino-quinazoline (1) was identified utilizing MultiCASE assisted drug design (MCADD) technology. Modification of compound 1 was conducted at the 2-, 4-, and 6-positions of the quinazoline ring for enhancement of cGMP- PDE inhibitory activity. The 6-substituted 2-(imidazol-1-yl)-quinazolines are 1000 times more potent in in vitro PDE V enzyme assay than the well-known inhibitor zaprinast. The 6-substituted derivatives of 2-(3- pyridyl)quinazoline 84 and 2-(imidazol-1-yl)quinazoline 86 exhibited more than 1000-fold selectivity for PDE V over the other four PDE isozymes. In addition, cGMP-PDE inhibitors 64, 65, and 73 were found to have an additional property of thromboxane synthesis inhibitory activity.