1579264-17-7Relevant academic research and scientific papers
A Metal-Organic Framework Br?nsted Acid Catalyst: Synthesis, Characterization and Application to the Generation of Quinone Methides for [4+2] Cycloadditions
Qi, Chao,Ramella, Daniele,Wensley, Allison M.,Luan, Yi
, p. 2604 - 2611 (2016)
A Br?nsted acid-derived metal-organic framework (MOF) has been developed to serve as an efficient heterogeneous catalyst for a [4+2] cycloaddition. Aromatic sulfonyl groups were successfully installed using commercially available anhydridic reagents during post-synthetic modifications. The MIL-101-NH-RSO3H MOF catalyst was fully characterized by SEM, PXRD, FTIR, TGA and N2adsorption/desorption isotherm. Furthermore, a novel [4+2] cycloaddition of substituted 2-vinyl-substituted phenol was evaluated. The MIL-101-NH-RSO3H catalyst showed superior catalytic capabilities when compared to a few other strong homogeneous Br?nsted acid catalysts. The MIL-101-NH-RSO3H catalyst is compatible with a variety of substituted substrates and it can be recycled five times without loss of yield or selectivity. (Figure presented.).
Organocatalytic asymmetric synthesis of 1,1-diarylethanes by transfer hydrogenation
Wang, Zhaobin,Ai, Fujin,Wang, Zheng,Zhao, Wanxiang,Zhu, Guangyu,Lin, Zhenyang,Sun, Jianwei
supporting information, p. 383 - 389 (2015/01/30)
A new organocatalytic transfer hydrogenation strategy for the asymmetric synthesis of 1,1-diarylethanes is described. Under mild conditions, a range of 1,1-diarylethanes substituted with an o-hydroxyphenyl or indole unit could be obtained with excellent efficiency and enantioselectivity. We also extended the protocol to an unprecedented asymmetric hydroarylation of 1,1-diarylalkenes with indoles for the synthesis of a range of highly enantioenriched 1,1,1-triarylethanes bearing acyclic all-carbon quaternary stereocenters. These diaryl- and triarylethanes exhibit impressive cytotoxicity against a number of human cancer cell lines. Preliminary mechanistic studies combined with DFT calculations provided important insight into the reaction mechanism.
Palladium-catalyzed synthesis of benzofurans via C-H activation/oxidation tandem reaction and its application to the synthesis of decursivine and serotobenine
Guo, Lei,Zhang, Fengying,Hu, Weimin,Li, Lei,Jia, Yanxing
supporting information, p. 3299 - 3302 (2014/03/21)
A new palladium-catalyzed method for the synthesis of benzofurans by reaction of 2-hydroxystyrenes and iodobenzenes via a C-H activation/oxidation tandem reaction has been unprecedentedly discovered. By using this strategy, the overall synthetic efficienc
