1579268-91-9Relevant academic research and scientific papers
Synthesis of fused-tricyclic indole derivatives through an acid-promoted skeletal rearrangement
Yokosaka, Takuya,Kanehira, Tomoya,Nakayama, Hiroki,Nemoto, Tetsuhiro,Hamada, Yasumasa
, p. 2151 - 2160 (2014/03/21)
We developed a novel method for synthesizing fused-tricyclic indole derivatives with a 3-aminomethyl indole motif through a reaction cascade involving ipso-Friedel-Crafts alkylation of phenols, rearomatization of the spirocyclohexadienone unit, and iso-Pictet-Spengler reaction. Using TFA as an acid promoter, six-, seven-, and eight-membered ring-fused indoles were obtained in 31-99% yield.
