1579269-06-9

Upstream product

• 139717-71-8 5-methoxy-N-(4-toluenesulfonyl)-1H-indole 
• 1579268-82-8 N-(3-hydroxy-3-(5-methoxy-1-tosyl-1H-indol-2-yl)propyl)-N-(4-methoxybenzyl)-4-methylbenzenesulfonamide 
• 1378478-43-3 C₁₈H₂₁NO₄S 

Downstream Products

• 1579269-23-0 5-(4-methoxyphenyl)-6-tosyl-1,2,3,4,5,6-hexahydroazepino[4,3-b]indole 
• 1579269-26-3 5-(4-methoxyphenyl)-2-((4-nitrophenyl)sulfonyl)-1,2,3,4,5,6-hexahydroazepino[4,3-b]indole 
• 1579269-29-6 5-(4-methoxyphenyl)-1,2,3,4,5,6-hexahydroazepino[4,3-b]indole 

Relevant academic research and scientific papers

Synthesis of fused-tricyclic indole derivatives through an acid-promoted skeletal rearrangement

We developed a novel method for synthesizing fused-tricyclic indole derivatives with a 3-aminomethyl indole motif through a reaction cascade involving ipso-Friedel-Crafts alkylation of phenols, rearomatization of the spirocyclohexadienone unit, and iso-Pictet-Spengler reaction. Using TFA as an acid promoter, six-, seven-, and eight-membered ring-fused indoles were obtained in 31-99% yield.