1579277-24-9Relevant academic research and scientific papers
Organocatalyzed highly diastereo- and enantioselective tandem sulfa-michael-mannich reaction of 2-mercaptoquinoline-3-carbaldimines with maleimides
Wu, Lulu,Wang, Youming,Song, Haibin,Tang, Liangfu,Zhou, Zhenghong,Tang, Chuchi
, p. 649 - 654 (2014/03/21)
A highly diastereo- and enantioselective organocatalyzed domino sulfa-Michael-Mannich reaction of 2-mercaptoquinoline-3-carbaldimines with maleimides has been developed. This approach provides a convenient and efficient access to multifuntionalized tetracyclic quinoline derivatives with three contiguous stereocenters in high yield with excellent stereoselectivity (up to >99:1 dr and >99 % ee). Four rings, three stereocenters: The asymmetric cascade sulfa-Michael-Mannich reaction of 2-mercapto-quinoline-3-carbaldimines with maleimides catalyzed by a bifunctional tertiary amine-thiourea affords tetracyclic quinoline derivatives with three contiguous stereocenters in high yield with excellent diastereo- (>99:1 dr) and enantioselectivities (90->99 % ee). Copyright
