1579296-27-7Relevant academic research and scientific papers
Facile assembly of 1-(4-haloisoquinolin-1-yl)ureas via a reaction of 2-alkynylbenzaldoxime, carbodiimide, and halide in water
Lai, Lifang,Wang, Huanhuan,Wu, Jie
supporting information, p. 2246 - 2250 (2014/03/21)
1-(4-Haloisoquinolin-1-yl)ureas are generated efficiently via a tandem reaction of 2-alkynylbenzaldoxime, carbodiimide, with halide in water. The process involves the generation of halonium ion in situ by employment of NaI/oxone or NaBr/oxone as the promoters. This green process proceeds smoothly and efficiently, accommodating a variety of substituents to generate the desired products.
