157947-74-5Relevant academic research and scientific papers
CROWN ETHER DERIVATIVES
-
Page/Page column 53, (2010/02/10)
The invention describes crown ether chelators, including crown ethers having the formula (A) or (B); and aza-substituted and thia-substituted analogs thereof. These crown ethers may be substituted by a dye moiety, a chemically reactive group, a conjugated substance, or a combination thereof. Chelators that are substituted by fluorescent dyes are particularly useful as indicators for metal cations, particularly Na and K ions, and particularly where binding of the target ion results in a change in the fluorescence properties of the indicator that can be correlated with the ion concentration. Methods are provided for utilizing reactive groups on the chelators for conjugation to dyes, lipids and polymers and methods for enhancing entry of the indicators into living cells.
Desymmetrization reactions: A convenient synthesis of aromatic diamide diamines
Picard,Arnaud,Tisnès
, p. 1471 - 1478 (2007/10/03)
A two-step process for the synthesis of various diamide diamines derived from 1,n-diamino benzene compounds is described. The amidation reaction is simple, mild, involves readily available bis(N-acylthiazolidine-2-thione) derivatives as acylating agents and requires only stoichiometric equivalents of diamine and acylating agents.
Access to Macrocyclic Lactams. Application to a New Series: the Dibenzotetralactams
Arnaud, Nathalie,Picard, Claude,Cazaux, Louis,Tisnes, Pierre
, p. 5531 - 5534 (2007/10/02)
A facile route is described for the synthesis of macrocyclic dibenzotetralactams derived from 1,2-diaminobenzene based on a stepwise approach using diacid dichlorides or mixed pivalic dianhydrides for ring closure.This method is applicable for the prepara
