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157947-87-0

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157947-87-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 157947-87-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,7,9,4 and 7 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 157947-87:
(8*1)+(7*5)+(6*7)+(5*9)+(4*4)+(3*7)+(2*8)+(1*7)=190
190 % 10 = 0
So 157947-87-0 is a valid CAS Registry Number.
InChI:InChI=1/C21H26N2O/c1-22(21(24)16-18-10-4-2-5-11-18)20(17-23-14-8-9-15-23)19-12-6-3-7-13-19/h2-7,10-13,20H,8-9,14-17H2,1H3

157947-87-0Downstream Products

157947-87-0Relevant articles and documents

Arylacetamide κ opioid receptor agonists with reduced cytochrome P450 2D6 inhibitory activity

Le Bourdonnec, Bertrand,Ajello, Christopher W.,Seida, Pamela R.,Susnow, Roberta G.,Cassel, Joel A.,Belanger, Serge,Stabley, Gabriel J.,DeHaven, Robert N.,DeHaven-Hudkins, Diane L.,Dolle, Roland E.

, p. 2647 - 2652 (2007/10/03)

Some κ opioid receptor agonists of the arylacetamide class, for example, ICI 199441 (1), were found to strongly inhibit the activity of cytochrome P450 2D6 (CYP2D6) (1: CYP2D6 IC50 = 26 nM). Certain analogs bearing a substituted sulfonylamino group, for example, 13, were discovered to have significantly reduced CYP2D6 inhibitory activity (13: CYP2D6 IC50 > 10 μM) while displaying high affinity toward the cloned human κ opioid receptor, good κ/δ and κ/μ selectivity, and potent in vitro and in vivo agonist activity.

Isothiocyanate-Substituted κ-Selective Opioid Receptor Ligands Derived from N-Methyl-N-phenylacetamide

Weerawarna, A. Ananda,Davis, Ronda D.,Nelson, Wendel L.

, p. 2856 - 2864 (2007/10/02)

The synthesis of isothiocyanate-substituted κ-selective opioid ligands derived from N-methyl-N-ethyl>phenylacetamide (8) and their effects in radioligand displacement assays are reported.Ligands 3-5 with the S-absolu

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