157947-92-7

Upstream product

• 37777-90-5 2-nitro-4,5-dichlorophenylacetic acid 
• 116508-51-1 (1S)-N-methyl-1-phenyl-2-(pyrrolidin-1-yl)ethanamine 
• 157947-91-6 N-methyl-N-<(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl>-2-nitro-4,5-dichlorophenylacetamide 

Relevant academic research and scientific papers

Kappa agonist compounds and pharmaceutical formulations thereof

Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compounds of formula IIIB have the structure: wherein R1, R2, R, Ar and n are as described in the specification.

Kappa agonist compounds and pharmaceutical formulations thereof

Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compounds of formulae I, II, IIA, III, IIIA, IIIB, IIIB-i, IV and IVA have the structure: wherein R1, R2, R3, R4; and X, X4, X5, X7, X9; Y, Z and n are as described in the specification.

Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith

Method for the prevention or treatment of pruritis by administering to a patient an antipruritic compound, or pharmaceutically acceptable salt thereof, of the class arylacetamide, which is exemplified by compounds of the formulae I, II, IIA, III, IV and IVA having the structures: and in which R1-4, X, X4, X5, X7, X9, Y and Z are as described in the specification.

Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith

Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided. The compound of formula I, having the structure: wherein R1, R2; X; and Ar Y, Z and n are as described in the specification.

Isothiocyanate-Substituted κ-Selective Opioid Receptor Ligands Derived from N-Methyl-N-phenylacetamide

The synthesis of isothiocyanate-substituted κ-selective opioid ligands derived from N-methyl-N-ethyl>phenylacetamide (8) and their effects in radioligand displacement assays are reported.Ligands 3-5 with the S-absolu