157948-85-1Relevant academic research and scientific papers
Zirconocene-mediated synthesis of 3,4-disubstituted piperidines and reduced isoquinolines
Kemp, Mark I.,Whitby, Richard J.,Coote, Steven J.
, p. 557 - 568 (2007/10/03)
Intramolecular cocyclisation of 4-azaocta-1,7-dienes, -1-en-7-ynes, -7- en-1-ynes and -1,7-diynes using 'zirconocene' equivalents affords 3-aza-8- zirconabicyclo[4.3.0]nonanes, -6-enes, -9-enes or -6,9-dienes. Protonolysis, iodinolysis, or carbonylation of these complexes affords 3,4-disubstitued piperidines. Exocyclic 1,3-dienes formed from the coupling/protonolysis of 4- azaocta-1,7-diynes react with activated dienophiles to yield reduced isoquinolines.
