15795-39-8

Basic information

• Product Name: 1-METHYL-1H-1,2,4-TRIAZOLE-5-AMINE
• Synonyms: 1-METHYL-1H-1,2,4-TRIAZOLE-5-AMINE;5-AMINO-1-METHYL-1,2,4-TRIAZOLE;1-Methyl-1H-1,2,4-triazol-5-amine;3-AMino-2-Methyl-2H-1,2,4-triazole;1H-1,2,4-Triazol-5-aMine,1-Methyl-;1-Methyl-1H-1,2,4-triazol-5-ylamine
• CAS NO: 15795-39-8
• Molecular Formula: C₃H₆N₄
• Molecular Weight: 98.11
• Mol File: 15795-39-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 281.9 °C at 760 mmHg
• Flash Point: 124.3 °C
• Appearance: /
• Density: 1.44 g/cm³
• Vapor Pressure: 0.00347mmHg at 25°C
• Refractive Index: 1.677
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.17±0.50(Predicted)
• CAS DataBase Reference: 1-METHYL-1H-1,2,4-TRIAZOLE-5-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-1H-1,2,4-TRIAZOLE-5-AMINE(15795-39-8)
• EPA Substance Registry System: 1-METHYL-1H-1,2,4-TRIAZOLE-5-AMINE(15795-39-8)

Safety Data

• Hazardous Substances Data: 15795-39-8(Hazardous Substances Data)

Usage

General Description

1-Methyl-1H-1,2,4-triazole-5-amine is a chemical compound with the molecular formula C3H5N3. It is a derivative of triazole, which is a five-membered ring with three nitrogen atoms and two carbon atoms. 1-METHYL-1H-1,2,4-TRIAZOLE-5-AMINE is a basic organic amine, with a nitrogen atom that can accept a proton and act as a base in chemical reactions. It is used as a building block in the synthesis of pharmaceuticals and agrochemicals. Additionally, it has applications in the production of specialty chemicals and as a reagent in organic synthesis. 1-Methyl-1H-1,2,4-triazole-5-amine is an important intermediate compound with diverse uses in the chemical industry.

InChI:InChI=1/C3H6N4/c1-7-3(4)5-2-6-7/h2H,1H3,(H2,4,5,6)

Upstream product

• 26621-29-4 1-methyl-5-nitro-1H-1,2,4-triazole 
• 39687-97-3 <(Dimethylamino)methylene>cyanamide 
• 60-34-4 methylhydrazine 
• 61-82-5 3⁽⁵⁾-amino-1,2,4-triazole 
• 74-88-4 methyl iodide 

Downstream Products

• 1218994-92-3 methyl (4-(4-fluorophenyl)-6-isopropyl-2-(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidine-5-carboxylate 
• 1443249-12-4 C₁₁H₉Cl₂FN₄OS 
• 1278406-12-4 methyl 4-(4-fluorophenyl)-6-isopropyl-2-[⁽¹⁴⁾C]-2-(1-methyl-1H-1,2,4-triazol-5-ylamino)pyrimidine-5-carboxylate 
• 1026025-03-5 C₃₀H₃₉FN₆O₄ 
• 127970-36-9 1-methyl-5-(4-N,N-dimethylamino-benzyliden)amino-1H-1,2,4-triazol 
• 127970-41-6 [1-(3,4-Dimethoxy-phenyl)-meth-(E)-ylidene]-(2-methyl-2H-[1,2,4]triazol-3-yl)-amine 
• 127970-38-1 1-methyl-5-(2,4-dichlor-benzyliden)amino-1H-1,2,4-triazol 
• 127970-37-0 1-methyl-5-(4-methoxy-benzyliden)amino-1H-1,2,4-triazol 
• 127970-39-2 1-methyl-5-(4-chlor-benzyliden)amino-1H-1,2,4-triazol 

Relevant articles and documents

Synthesis method of 2-methyl-1, 2, 4-triazole-3-amine

The invention relates to a synthesis method of 2-methyl-1, 2, 4-triazole-3-amine, and mainly solves the technical problem that no suitable industrial synthesis method exists at present. The method comprises the following three steps: 1, reacting a compound 1 in a solvent 1, 4-dioxane with added N, N-dimethylformamide dimethyl acetal to obtain a compound 2; 2, reacting the compound 2 with triphenylphosphine and diisopropyl azodicarboxylate in methanol to obtain a compound 3; and 3, reacting the compound 3 with sodium hydroxide in methanol and water to obtain a final compound 4, wherein the reaction formula is described in the specification.

Synthesis of 1-Alkyl-5-amino-1,2,4-triazoles Based on Nucleophilic Substitution and Reduction Reactions

A series of 1-alkyl-5-amino-1H-1,2,4-triazoles were synthesized starting from 3,5-dibromo-1H- 1,2,4-triazole by alkylation and subsequent nucleophilic substitution of the 5-bromine atom by azido group, reduction of the latter to amino group, and hydrodebromination.

Development of a scaleable process for the synthesis of a next-generation statin

This manuscript details the process research and development of a convergent and safe approach to 1 on a multikilo scale. Specific highlights of the process development efforts will be described, including the development of a dehydrogenation method for d