15795-53-6

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 529-20-4 2-methylphenyl aldehyde 

Downstream Products

• 97397-63-2 6,6-Dimethyl-1-(2-methyl-benzyl)-5,7-dioxa-spiro[2.5]octane-4,8-dione 
• 97381-38-9 6,6-Dimethyl-1-o-tolyl-5,7-dioxa-spiro[2.5]octane-4,8-dione 
• 118-90-1 ortho-methylbenzoic acid 
• 75307-59-4 5-Hydroxy-Meldrums Saeure 
• 529-20-4 2-methylphenyl aldehyde 
• 2963-64-6 2-(2-methylphenyl)benzimidazole 
• 97364-43-7 (1S,2R)-1-Amino-2-o-tolyl-cyclopropanecarboxylic acid; hydrochloride 
• 97364-60-8 (1S,2R)-1-Methoxycarbonylamino-2-o-tolyl-cyclopropanecarboxylic acid 
• 97364-52-8 (1R,2R)-1-Carbamoyl-2-o-tolyl-cyclopropanecarboxylic acid 
• 1343337-62-1 C₁₁H₁₁F₃O₂ 
• 1467065-68-4 methyl 4,4,4-trifluoro-3-(o-tolyl)butanoate 

Relevant academic research and scientific papers

Boron/zinc exchange for the conjugate arylation of unsaturated Meldrum's acid derivatives

An approach for the conjugate arylation reaction of unsaturated Meldrum's acid derivatives is reported. The reaction takes place through a Boron-Zinc exchange reaction between arylboronic acids and diethylzinc and the subsequent transfer of thus generated reactive aryl groups to the β-position of the double bond of the Meldrum's derivatives. The compounds obtained are valuable synthetic intermediates and can give rise to bioactive molecules such as β,β-disubstituted carboxylic acids and amides.

Synthesis of new guanidium-meldrum acid zwitterionic salts and dynamic NMR study of rotational energy barrier around C-NH bond of guanidine moiety

Synthesis of the Guanidium-Meldrum acid zwitterionic salts was developed through a three component reaction of 2, 2-dimethyl-1, 3-dioxane-4, 6-dione (Meldrum acid), aromatic aldehydes and N, N, N', N'- Tetramethyl-guanidine in benzen at room temperature.

Enantioselective rhodium-catalyzed conjugate alkynylation of 5-benzylidene Meldrum's acids with TMS-acetylene

(Chemical Equation Presented) The enantioselective alkynylation of benzylidene Meldrum's acids has been successfully achieved through rhodium-catalyzed addition of TMS-acetylene in the presence of bisphosphine ligand 3,5-Xylyl-MeOBIPHEP. The resulting Mel

A general and practical preparation of alkylidene Meldrum's acids

Although many methods have been reported for the Knoevenagel condensation of aldehydes and Meldrum's acid, most are not general or use unconventional reagents and conditions. We have found that alkylidene Meldrum's acids form readily in benzene solution u