15795-56-9

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 135-02-4 ortho-anisaldehyde 
• 23340-26-3 5-methylene-2,2-dimethyl-1,3-dioxane-4,6-dione 

Downstream Products

• 131447-66-0 4-(2-Methoxy-phenyl)-1,7,7-trimethyl-4,6,7,8-tetrahydro-1H,3H-quinoline-2,5-dione 
• 531-81-7 2-oxo-2H-chromene-3-carboxylic acid 
• 579-75-9 2-Methoxybenzoic acid 
• 75307-59-4 5-Hydroxy-Meldrums Saeure 
• 135-02-4 ortho-anisaldehyde 
• 1007392-34-8 (2E)-4-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)-4-(2-methoxyphenyl)but-2-enyl ethyl carbonate 
• 1007392-20-2 (2E)-4-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)-4-(2-methoxyphenyl)but-2-enyl acetate 
• 1030620-33-7 5-(2-methoxybenzyl)-2,2-dimethyl[1,3]dioxane-4,6-dione 
• 1196033-48-3 (4R,2E)-4-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)-4-(2-methoxyphenyl)but-2-enyl ethyl carbonate 
• 1204474-12-3 (R)-5-(1-(2-methoxyphenyl)but-2-ynyl)-2,2-dimethyl-1,3-dioxane-4,6-dione 

Relevant academic research and scientific papers

Bentonite catalyzed an efficient and green synthesis of arylidene meldrum's acid derivatives in aqueous media

In the present paper, a simple, highly efficient, and environmentally friendly protocol was proposed for the Knoevenagel condensation reaction of aromatic aldehydes using Meldrum’s acid (2,2-dimethyl-4,6-dioxo-1,3-dioxane) with bentonite as an available n

Boron/zinc exchange for the conjugate arylation of unsaturated Meldrum's acid derivatives

An approach for the conjugate arylation reaction of unsaturated Meldrum's acid derivatives is reported. The reaction takes place through a Boron-Zinc exchange reaction between arylboronic acids and diethylzinc and the subsequent transfer of thus generated reactive aryl groups to the β-position of the double bond of the Meldrum's derivatives. The compounds obtained are valuable synthetic intermediates and can give rise to bioactive molecules such as β,β-disubstituted carboxylic acids and amides.

Microwave-associate synthesis of Co3O4 nanoparticles as an effcient nanocatalyst for the synthesis of arylidene barbituric and Meldrum's acid derivatives in green media

In this study, Co3O4 nanocatalysts were constructed in environmentally appropriate conditions using controlled, effective, and facile microwave method. The final nanostructures were characterized by SEM, XRD, and TEM analyses. The products had a small size distribution, homogeneous morphology, and crystallographic structures associated with the formation of Co3O4 nanostructures. Moreover, EDS mapping analysis confirmed the existence of Co and O elements in the final structure, and the magnetic properties of the samples were investigated by VSM. The application of this nanostructure in a catalytic process was further examined, and the results suggested that it could be used as a novel candidate for the synthesis of arylidene barbituric and Meldrum,s acid through Knoevenagel condensation of aldehydes by barbituric and Meldrum,s acid in aqueous media. The high yield of these nanocatalysts would be justified by the nature of the nanostructure as well as the experimental procedure developed in this study, which affected the physicochemical features of the products.

A transition metal free expedient approach for the C[dbnd]C bond cleavage of arylidene Meldrum's acid and malononitrile derivatives

A transition metal free expedient approach for the C[dbnd]C bond cleavage of electron deficient alkenes such as arylidene Meldrum's acid and malononitrile derivatives are discussed. The C[dbnd]C bond of these compound were cleaved to benzoic acid in good yield at high temperature. Most importantly, with oxone in CH3CN/H2O at 45 °C or m-CPBA in DCM or NaClO2 in THF/H2O or PIDA in THF at room temperature furnished benzaldehyde derivatives selectively in excellent yields.

Discovery and preliminary SAR of 5-arylidene-2,2-dimethyl-1,3-dioxane-4,6- diones as platelet aggregation inhibitors

We herein document the discovery of 5-arylidene-2,2-dimethyl-1,3-dioxane-4, 6-diones as a novel family of platelet aggregation inhibitors. The preliminary optimization study enabled us to establish the most salient features of the structure-activity relat

Knoevenagel condensation of aldehydes with Meldrum's acid in ionic liquids

The Knoevenagel condensation of Meldrum's acid with aromatic aldehydes proceeded efficiently in the recyclable ionic liquid [bmim]BF4 at room temperature in the presence of catalytic amounts of piperidine.

A practical synthesis of α-substituted tert-butyl acrylates from meldrum's acid and aldehydes

An expeditious synthesis of α-substituted tert-butyl acrylates from commercially available aldehydes and Meldrum's acid has been established. The method benefits from a telescoped condensation-reduction sequence to afford 5-monosubstituted Meldrum's acid

Asymmetrie addition of alkenylstannanes to alkylidene meldrum's acids

Herein, we describe enantioselective addition of alkenyltin reagents possessing a reactive and sensitive allylic functionality not readily available to other classes of alkenyl metals. This method is enabled by the use of highly electrophilic alkylidene M

Sequential Rh(l)/Pd-catalyzed 1,4-addition/Lntramolecular allylation: Stereocontrolled construction of γ-butyrolactones and cyclopropanes

The rhodium-catalyzed conjugate addition of functionalized vinyltin reagents to alkylidene Meldrum's acids, followed by Pd-catalyzed intramolecular allylation, is a direct entry into vinyl-substituted y-lactones via Oalkylation and vinylcyclopropanes via

A general and practical preparation of alkylidene Meldrum's acids

Although many methods have been reported for the Knoevenagel condensation of aldehydes and Meldrum's acid, most are not general or use unconventional reagents and conditions. We have found that alkylidene Meldrum's acids form readily in benzene solution u