15795-58-1

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 100-83-4 meta-hydroxybenzaldehyde 

Downstream Products

• 1189171-00-3 (R)-5-(1-(3-hydroxyphenyl)-3-(trimethylsilyl)prop-2-ynyl)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 1142214-45-6 C₃₀H₃₃FO₄ 
• 1142214-62-7 [3H]-AM 1638 
• 1142223-08-2 methyl (3S)-3-cyclopropyl-3-(3-hydroxyphenyl)propanoate 
• 1142223-06-0 methyl (3R)-3-cyclopropyl-3-(3-hydroxyphenyl)propanoate 
• 1393841-41-2 C₃₄H₃₇FO₄ 
• 1142224-60-9 3-cyclopropyl-3-(3-hydroxyphenyl)propanoic acid 
• 1142223-02-6 5-(cyclopropyl(3-hydroxyphenyl)methyl)-2,2-dimethyl-1,3-dioxane-4,6-dione 

Relevant academic research and scientific papers

Bentonite catalyzed an efficient and green synthesis of arylidene meldrum's acid derivatives in aqueous media

In the present paper, a simple, highly efficient, and environmentally friendly protocol was proposed for the Knoevenagel condensation reaction of aromatic aldehydes using Meldrum’s acid (2,2-dimethyl-4,6-dioxo-1,3-dioxane) with bentonite as an available n

Design and Identification of a GPR40 Full Agonist (SCO-267) Possessing a 2-Carbamoylphenyl Piperidine Moiety

GPR40/FFAR1 is a G-protein-coupled receptor expressed in pancreatic β-cells and enteroendocrine cells. GPR40 activation stimulates secretions of insulin and incretin, both of which are the pivotal regulators of glycemic control. Therefore, a GPR40 agonist

Microwave-associate synthesis of Co3O4 nanoparticles as an effcient nanocatalyst for the synthesis of arylidene barbituric and Meldrum's acid derivatives in green media

In this study, Co3O4 nanocatalysts were constructed in environmentally appropriate conditions using controlled, effective, and facile microwave method. The final nanostructures were characterized by SEM, XRD, and TEM analyses. The products had a small size distribution, homogeneous morphology, and crystallographic structures associated with the formation of Co3O4 nanostructures. Moreover, EDS mapping analysis confirmed the existence of Co and O elements in the final structure, and the magnetic properties of the samples were investigated by VSM. The application of this nanostructure in a catalytic process was further examined, and the results suggested that it could be used as a novel candidate for the synthesis of arylidene barbituric and Meldrum,s acid through Knoevenagel condensation of aldehydes by barbituric and Meldrum,s acid in aqueous media. The high yield of these nanocatalysts would be justified by the nature of the nanostructure as well as the experimental procedure developed in this study, which affected the physicochemical features of the products.

A class of GPR40 agonist compounds with amide structure, and uses thereof

The present invention relates to a class of amide compounds with a novel structure, and a pharmaceutical composition thereof, wherein the structure of the amide compound is represented by a general formula (I). According to the present invention, the amide compound (I) can regulate GPR40 activity, and can be used for GPR40 activity related diseases such as diabetes and metabolic syndrome. The formula I is defined in the specification.

CYCLOHEXYL GPR40 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES

Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are represented by Formula (I) as follows: (Formula (I)) wherein R1, R2, R3, A, W, L, Ra, and G are defined herein: and by Formula (II) as follows: (Formula (II)) wherein R1B, WB, LB, and GB are defined herein.

AROMATIC RING COMPOUND

Provided is an aromatic ring compound having a GPR40 agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity, and is useful as an agent for the prophylaxis or treatment of diabetes and the like.

Synthesis of 5-arylidene-2,2-dimethyl-1,3-dioxane-4,6-diones and coumarin-3-carboxylic acids via reaction of nitrones and Meldrum's acid

A variety of nitrones have been synthesized and reacted with Meldrum's acid without the aid of any catalysts. Selectively, 5- arylidene-2,2-dimethyl-1,3- dioxane-4,6-diones have been obtained with excellent yields under environmentally benign reaction conditions. Whereas, nitrone of salisylaldehydes with Meldrum's acid afford cyclized products i.e. coumarin-3- carboxylic acids.

Discovery of AM-1638: A potent and orally bioavailable GPR40/FFA1 full agonist

GPR40 (FFA1) is a G-protein-coupled receptor, primarily expressed in pancreatic islets, the activation of which elicits increased insulin secretion only in the presence of elevated glucose levels. A potent, orally bioavailable small molecule GPR40 agonist

Nickel nanoparticles catalyzed chemoselective Knoevenagel condensation of Meldrum's acid and tandem enol lactonizations via cascade cyclization sequence

A novel protocol has been reported wherein, polyethylene glycol (PEG) stabilized nickel nanoparticles have been used as catalyst for chemoselective Knoevenagel condensation of aromatic aldehydes and Meldrum's acid to give 5-arylidene Meldrum's acid which underwent tandem enol lactonization by Michael addition/cyclization sequence with active methylene compounds in the presence of Ni nanoparticles to give corresponding enol lactone derivatives.

A novel light induced Knoevenagel condensation of Meldrum's acid with aromatic aldehydes in aqueous ethanol

A highly efficient environment-friendly photochemical methodology has been developed for the condensation of Meldrum's acid with aromatic aldehydes in water-ethanol solution sans any catalyst, support or promoter.